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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Immunol
2016 ; 38
(ä): 39-44
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PTX3, a humoral pattern recognition molecule at the interface between microbe and
matrix recognition
#MMPMID26650391
Garlanda C
; Jaillon S
; Doni A
; Bottazzi B
; Mantovani A
Curr Opin Immunol
2016[Feb]; 38
(ä): 39-44
PMID26650391
show ga
Innate immunity consists of a cellular and a humoral arm. PTX3 is a fluid patter
recognition molecule (PRM) with antibody-like properties. Gene targeted mice and
genetic associations in humans suggest that PTX3 plays a non-redundant role in
resistance against selected pathogens (e.g. Aspergillus fumigatus, Pseudomonas
aeruginosa, uropathogenic Escherichia coli) and in the regulation of
inflammation. PTX3 acts as an extrinsic oncosuppressor by taming complement
elicited tumor-promoting inflammation. Recent results indicate that, by
interacting with provisional matrix components, PTX3 contributes to the
orchestration of tissue repair. An acidic pH sets PTX3 in a tissue repair mode,
while retaining anti-microbial recognition. Based on these data and scattered
information on humoral PRM and matrix components, we surmise that matrix and
microbial recognition are related functions in evolution.