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10.1016/j.coi.2015.11.002

http://scihub22266oqcxt.onion/10.1016/j.coi.2015.11.002
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suck abstract from ncbi


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pmid26650391
      Curr+Opin+Immunol 2016 ; 38 (ä): 39-44
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  • PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition #MMPMID26650391
  • Garlanda C ; Jaillon S ; Doni A ; Bottazzi B ; Mantovani A
  • Curr Opin Immunol 2016[Feb]; 38 (ä): 39-44 PMID26650391 show ga
  • Innate immunity consists of a cellular and a humoral arm. PTX3 is a fluid patter recognition molecule (PRM) with antibody-like properties. Gene targeted mice and genetic associations in humans suggest that PTX3 plays a non-redundant role in resistance against selected pathogens (e.g. Aspergillus fumigatus, Pseudomonas aeruginosa, uropathogenic Escherichia coli) and in the regulation of inflammation. PTX3 acts as an extrinsic oncosuppressor by taming complement elicited tumor-promoting inflammation. Recent results indicate that, by interacting with provisional matrix components, PTX3 contributes to the orchestration of tissue repair. An acidic pH sets PTX3 in a tissue repair mode, while retaining anti-microbial recognition. Based on these data and scattered information on humoral PRM and matrix components, we surmise that matrix and microbial recognition are related functions in evolution.
  • |*Host-Pathogen Interactions [MESH]
  • |*Immunity, Humoral [MESH]
  • |Animals [MESH]
  • |Bacterial Infections/genetics/*immunology/microbiology/pathology [MESH]
  • |C-Reactive Protein/genetics/*immunology [MESH]
  • |Complement System Proteins/genetics/immunology [MESH]
  • |Extracellular Matrix Proteins/genetics/immunology [MESH]
  • |Gene Expression Regulation [MESH]
  • |Humans [MESH]
  • |Immunity, Innate [MESH]
  • |Inflammation [MESH]
  • |Mice [MESH]
  • |Neoplasms/genetics/*immunology/pathology [MESH]
  • |Nerve Tissue Proteins/genetics/*immunology [MESH]
  • |Receptors, Pattern Recognition/genetics/immunology [MESH]
  • |Serum Amyloid P-Component/genetics/*immunology [MESH]


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