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10.1210/me.2014-1062 http://scihub22266oqcxt.onion/10.1210/me.2014-1062 C5414825!5414825!24766141     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Endocrinol 2014 ; 28 (7): 999-1011 Nephropedia Template TP {{tp|p=24766141|t=2014. Minireview: New Molecular Mediators of Glucocorticoid Receptor Activity in Metabolic Tissues |pdf=|usr=}}{{24766141}} gab.com Text Minireview: New Molecular Mediators of Glucocorticoid Receptor Activity in Metabolic Tissues JO: Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=24766141 #FOAvip The glucocorticoid receptor (GR) was one of the first nuclear hormone receptors cloned and represents one of the most effective drug targets available today for the treatment of severe inflammation. The physiologic consequences of endogenous or exogenous glucocorticoid excess are well established and include hyperglycemia, insulin resistance, fatty liver, obesity, and muscle wasting. However, at the molecular and tissue-specific level, there are still many unknown protein mediators of glucocorticoid response and thus, much remains to be uncovered that will help determine whether activation of the GR can be tailored to improve therapeutic efficacy while minimizing unwanted side effects. This review summarizes recent discoveries of tissue-selective modulators of glucocorticoid signaling that are important in mediating the unwanted side effects of therapeutic glucocorticoid use, emphasizing the downstream molecular effects of GR activation in the liver, adipose tissue, muscle, and pancreas. Twit Text FOAVip Minireview: New Molecular Mediators of Glucocorticoid Receptor Activity in Metabolic Tissues ????Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=24766141 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24766141 #FOAvip English Wikipedia <ref>{{Cite pmid|24766141}}</ref> Minireview: New Molecular Mediators of Glucocorticoid Receptor Activity in Metabolic Tissues #MMPMID24766141 Patel R; Williams-Dautovich J; Cummins CL Mol Endocrinol 2014[Jul]; 28 (7): 999-1011 PMID24766141show ga The glucocorticoid receptor (GR) was one of the first nuclear hormone receptors cloned and represents one of the most effective drug targets available today for the treatment of severe inflammation. The physiologic consequences of endogenous or exogenous glucocorticoid excess are well established and include hyperglycemia, insulin resistance, fatty liver, obesity, and muscle wasting. However, at the molecular and tissue-specific level, there are still many unknown protein mediators of glucocorticoid response and thus, much remains to be uncovered that will help determine whether activation of the GR can be tailored to improve therapeutic efficacy while minimizing unwanted side effects. This review summarizes recent discoveries of tissue-selective modulators of glucocorticoid signaling that are important in mediating the unwanted side effects of therapeutic glucocorticoid use, emphasizing the downstream molecular effects of GR activation in the liver, adipose tissue, muscle, and pancreas. äMinireview: New Molecular Mediators of Glucocorticoid Receptor Activit(epmc).pdf DeepDyve Pubget Overpricing