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10.1172/jci.insight.90201 http://scihub22266oqcxt.onion/10.1172/jci.insight.90201 C5414554!5414554!28469081     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight ä ; 2 (9): ä Nephropedia Template TP {{tp|p=28469081|t=ä. C3d regulates immune checkpoint blockade and enhances antitumor immunity |pdf=|usr=}}{{28469081}} gab.com Text C3d regulates immune checkpoint blockade and enhances antitumor immunity JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28469081 #FOAvip Despite expression of immunogenic polypeptides, tumors escape immune surveillance by engaging T cell checkpoint regulators and expanding Tregs, among other mechanisms. What orchestrates these controls is unknown. We report that free C3d, a fragment of the third component of complement, inside tumor cells ? or associated with irradiated tumor cells and unattached to antigen ? recruits, accelerates, and amplifies antitumor T cell responses, allowing immunity to reverse or even to prevent tumor growth. C3d enhances antitumor immunity independently of B cells, NK cells, or antibodies, but it does so by increasing tumor infiltrating CD8+ lymphocytes, by depleting Tregs, and by suppressing expression of programmed cell death protein 1 (PD-1) by T cells. These properties of C3d appear specific for the tumor and dependent on complement receptor 2, and they incur no obvious systemic toxicity. The heretofore unrecognized properties of free C3d suggest that protein might determine the effectiveness of immune surveillance and that increasing availability of the protein might prove advantageous in the treatment or prevention of cancer and premalignant conditions. Twit Text FOAVip C3d regulates immune checkpoint blockade and enhances antitumor immunity ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28469081 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28469081 #FOAvip English Wikipedia <ref>{{Cite pmid|28469081}}</ref> C3d regulates immune checkpoint blockade and enhances antitumor immunity #MMPMID28469081 Platt JL; Silva I; Balin SJ; Lefferts AR; Farkash E; Ross TM; Carroll MC; Cascalho M JCI Insight ä[]; 2 (9): ä PMID28469081show ga Despite expression of immunogenic polypeptides, tumors escape immune surveillance by engaging T cell checkpoint regulators and expanding Tregs, among other mechanisms. What orchestrates these controls is unknown. We report that free C3d, a fragment of the third component of complement, inside tumor cells ? or associated with irradiated tumor cells and unattached to antigen ? recruits, accelerates, and amplifies antitumor T cell responses, allowing immunity to reverse or even to prevent tumor growth. C3d enhances antitumor immunity independently of B cells, NK cells, or antibodies, but it does so by increasing tumor infiltrating CD8+ lymphocytes, by depleting Tregs, and by suppressing expression of programmed cell death protein 1 (PD-1) by T cells. These properties of C3d appear specific for the tumor and dependent on complement receptor 2, and they incur no obvious systemic toxicity. The heretofore unrecognized properties of free C3d suggest that protein might determine the effectiveness of immune surveillance and that increasing availability of the protein might prove advantageous in the treatment or prevention of cancer and premalignant conditions. äC3d regulates immune checkpoint blockade and enhances antitumor immuni(epmc).pdf DeepDyve Pubget Overpricing