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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 World+J+Surg+Oncol
2017 ; 15
(1
): 92
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gab.com Text
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English Wikipedia
Symptoms and signs associated with benign and malignant proximal fibular tumors:
a clinicopathological analysis of 52 cases
#MMPMID28464896
Sun T
; Wang L
; Guo C
; Zhang G
; Hu W
World J Surg Oncol
2017[May]; 15
(1
): 92
PMID28464896
show ga
BACKGROUND: Malignant tumors in the proximal fibula are rare but
life-threatening; however, biopsy is not routine due to the high risk of peroneal
nerve injury. Our aim was to determine preoperative clinical indicators of
malignancy. METHODS: Between 2004 and 2016, 52 consecutive patients with proximal
fibular tumors were retrospectively reviewed. Details of the clinicopathological
characteristics including age, gender, location of tumors, the presenting
symptoms, the duration of symptoms, and pathological diagnosis were collected.
Descriptive statistics were calculated, and univariate and multivariate
regression were performed. RESULTS: Of these 52 patients, 84.6% had benign tumors
and 15.4% malignant tumors. The most common benign tumors were osteochondromas
(46.2%), followed by enchondromas (13.5%) and giant cell tumors (13.5%). The most
common malignancy was osteosarcomas (11.5%). The most common presenting symptoms
were a palpable mass (52.0%) and pain (46.2%). Pain was the most sensitive (100%)
and fourth specific (64%); both high skin temperature and peroneal nerve
compression had the highest specificity (98%) and third sensitivity (64%); change
in symptoms had the second highest specificity (89%) while 50% sensitivity. Using
multivariate regression, palpable pain, high skin temperature, and peroneal nerve
compression symptoms were predictors of malignancy. CONCLUSIONS: Most tumors in
the proximal fibula are benign, and the malignancy is rare. Palpable pain,
peroneal nerve compression symptoms, and high skin temperature were specific in
predicting malignancy.