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10.1098/rsos.160850 http://scihub22266oqcxt.onion/10.1098/rsos.160850 C5414242!5414242!28484605     free     free     free       R+Soc+Open+Sci 2017 ; 4 (4): ä Nephropedia Template TP {{tp|p=28484605|t=2017. How do red blood cells know when to die?|pdf=|usr=}}{{28484605}} gab.com Text How do red blood cells know when to die JO: R Soc Open Sci http://www.kidney.de/pget.php?&tw=1&pmid=28484605 #FOAvip Human red blood cells (RBCs) are normally phagocytized by macrophages of splenic and hepatic sinusoids at 120 days of age. The destruction of RBCs is ultimately controlled by antagonist effects of phosphatidylserine (PS) and CD47 on the phagocytic activity of macrophages. In this work, we introduce a conceptual model that explains RBC lifespan as a consequence of the dynamics of these molecules. Specifically, we suggest that PS and CD47 define a molecular algorithm that sets the timing of RBC phagocytosis. We show that significant changes in RBC lifespan described in the literature can be explained as alternative outcomes of this algorithm when it is executed in different conditions of oxygen availability. The theoretical model introduced here provides a unified framework to understand a variety of empirical observations regarding RBC biology. It also highlights the role of RBC lifespan as a key element of RBC homeostasis. Twit Text FOAVip How do red blood cells know when to die ????R Soc Open Sci http://www.kidney.de/pget.php?&tw=1&pmid=28484605 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28484605 #FOAvip English Wikipedia <ref>{{Cite pmid|28484605}}</ref> How do red blood cells know when to die? #MMPMID28484605 Arias CF; Arias CF R Soc Open Sci 2017[Apr]; 4 (4): ä PMID28484605show ga Human red blood cells (RBCs) are normally phagocytized by macrophages of splenic and hepatic sinusoids at 120 days of age. The destruction of RBCs is ultimately controlled by antagonist effects of phosphatidylserine (PS) and CD47 on the phagocytic activity of macrophages. In this work, we introduce a conceptual model that explains RBC lifespan as a consequence of the dynamics of these molecules. Specifically, we suggest that PS and CD47 define a molecular algorithm that sets the timing of RBC phagocytosis. We show that significant changes in RBC lifespan described in the literature can be explained as alternative outcomes of this algorithm when it is executed in different conditions of oxygen availability. The theoretical model introduced here provides a unified framework to understand a variety of empirical observations regarding RBC biology. It also highlights the role of RBC lifespan as a key element of RBC homeostasis. äHow do red blood cells know when to die?(epmc).pdf DeepDyve Pubget Overpricing