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10.1186/s13075-017-1295-z http://scihub22266oqcxt.onion/10.1186/s13075-017-1295-z C5414163!5414163 !28464939     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28464939 &cmd=llinks): Failed to open stream: HTTP request failed! 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Circulating DNA in rheumatoid arthritis: pathological changes and association with clinically used serological markers |pdf=|usr=}}{{28464939 }} gab.com Text Circulating DNA in rheumatoid arthritis: pathological changes and association with clinically used serological markers JO: Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=28464939 #FOAvip BACKGROUND: Early diagnosis of rheumatoid arthritis (RA) is crucial to providing effective therapy and often hampered by unspecific clinical manifestations. Elevated levels of extracellular circulating DNA (cirDNA) in patients with autoimmune disease were found to be associated with etiopathogenesis. To our knowledge, this is the first study to investigate the putative diagnostic use of cirDNA in RA and its association with disease activity. METHODS: Blood samples were taken from 63 healthy subjects (HS) and 74 patients with RA. cirDNA was extracted from plasma and cell surface-bound cirDNA fractions (csbDNA). cirDNA concentration was measured by quantitative real-time polymerase chain reaction. Rheumatoid factor was analyzed by immunonephelometry, whereas C-reactive protein and anticitrullinated protein/peptide antibodies (ACPA) were detected by enzyme-linked immunosorbent assay. RESULTS: Plasma cirDNA was significantly elevated in patients with RA compared with HS (12.0 versus 8.4 ng/ml, p?<?0.01). In contrast, nuclear csbDNA (n-csbDNA) was significantly decreased (24.0 versus 50.8 ng/ml, p?<?0.01), whereas mitochondrial csbDNA (m-csbDNA) was elevated (1.44?×?10(6) copies/ml versus 0.58?×?10(6) copies/ml, p?<?0.05) in RA. The combination of csbDNA (mitochondrial?+?nuclear) with ACPA reveals the best positive/negative likelihood ratios (LRs) for the discrimination RA from HS (LR+ 61.00, LR- 0.03) in contrast to ACPA (LR+ 9.00, LR- 0.19) or csbDNA (LR+ 8.00, LR- 0.18) alone. CONCLUSIONS: Nuclear and mitochondrial cirDNA levels in plasma and on the surface of blood cells are modulated in RA. Combination of cirDNA values with ACPA can improve the serological diagnosis of RA. Twit Text FOAVip Circulating DNA in rheumatoid arthritis: pathological changes and association with clinically used serological markers ????Arthritis Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=28464939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28464939 #FOAvip English Wikipedia <ref>{{Cite pmid|28464939 }}</ref> Circulating DNA in rheumatoid arthritis: pathological changes and association with clinically used serological markers #MMPMID28464939 Rykova E ; Sizikov A ; Roggenbuck D ; Antonenko O ; Bryzgalov L ; Morozkin E ; Skvortsova K ; Vlassov V ; Laktionov P ; Kozlov V Arthritis Res Ther 2017[May]; 19 (1 ): 85 PMID28464939 show ga BACKGROUND: Early diagnosis of rheumatoid arthritis (RA) is crucial to providing effective therapy and often hampered by unspecific clinical manifestations. Elevated levels of extracellular circulating DNA (cirDNA) in patients with autoimmune disease were found to be associated with etiopathogenesis. To our knowledge, this is the first study to investigate the putative diagnostic use of cirDNA in RA and its association with disease activity. METHODS: Blood samples were taken from 63 healthy subjects (HS) and 74 patients with RA. cirDNA was extracted from plasma and cell surface-bound cirDNA fractions (csbDNA). cirDNA concentration was measured by quantitative real-time polymerase chain reaction. Rheumatoid factor was analyzed by immunonephelometry, whereas C-reactive protein and anticitrullinated protein/peptide antibodies (ACPA) were detected by enzyme-linked immunosorbent assay. RESULTS: Plasma cirDNA was significantly elevated in patients with RA compared with HS (12.0 versus 8.4 ng/ml, p? |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Arthritis, Rheumatoid/*blood/*diagnosis [MESH] |Autoantibodies/blood [MESH] |Biomarkers/blood [MESH] |Cell-Free Nucleic Acids/*blood [MESH] |Cohort Studies [MESH] |Early Diagnosis [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Principal Component Analysis [MESH] |Random Allocation [MESH]Circulating DNA in rheumatoid arthritis: pathological changes and asso(epmc).pdf DeepDyve Pubget Overpricing