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2017 ; 4
(1
): ofw255
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
A Proposed New Classification of Skin and Soft Tissue Infections Modeled on the
Subset of Diabetic Foot Infection
#MMPMID28480249
Lipsky BA
; Silverman MH
; Joseph WS
Open Forum Infect Dis
2017[Win]; 4
(1
): ofw255
PMID28480249
show ga
Schemes for classifying skin and soft tissue infections (SSTIs) pose limitations
for clinicians and regulatory agencies. Diabetic foot infections (DFIs) are a
subset of SSTIs. We developed and are proposing a classification to harmonize
current schemes for SSTIs and DFIs. Existing schemes for classifying SSTIs are
limited in both their usefulness to clinicians and to regulatory agencies. The
guidelines on SSTI from the Infectious Diseases Society of America (IDSA) and the
guidance from the US Food and Drug Administration do not adequately address many
types of wound infections. However, guidelines developed by the IDSA for DFIs
provide a classification scheme that has been validated and widely used. Diabetic
foot infections are similar to SSTIs in pathophysiology, microbiology, and
treatment and can be seen as a subset of SSTI. Thus, based on the documents noted
above, and our review of the literature, we have developed a proposed
classification scheme for SSTI that harmonizes well with the DFI classification.
We believe this new scheme will assist clinicians in classifying most wound
infections and potentially aid regulatory agencies in testing and approving new
antimicrobials for these infections.