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10.1038/ncomms15067 http://scihub22266oqcxt.onion/10.1038/ncomms15067 C5413949!5413949!28429709     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28429709|t=2017. T follicular helper and T follicular regulatory cells have different TCR specificity |pdf=|usr=}}{{28429709}} gab.com Text T follicular helper and T follicular regulatory cells have different TCR specificity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28429709 #FOAvip Immunization leads to the formation of germinal centres (GCs) that contain both T follicular helper (Tfh) and T follicular regulatory (Tfr) cells. Whether T-cell receptor (TCR) specificity defines the differential functions of Tfh and Tfr cells is unclear. Here we show that antigen-specific T cells after immunization are preferentially recruited to the GC to become Tfh cells, but not Tfr cells. Tfh cells, but not Tfr cells, also proliferate efficiently on restimulation with the same immunizing antigen in vitro. Ex vivo TCR repertoire analysis shows that immunization induces oligoclonal expansion of Tfh cells. By contrast, the Tfr pool has a TCR repertoire that more closely resembles that of regulatory T (Treg) cells. Our data thus indicate that the GC Tfh and Tfr pools are generated from distinct TCR repertoires, with Tfh cells expressing antigen-responsive TCRs to promote antibody responses, and Tfr cells expressing potentially autoreactive TCRs to suppress autoimmunity. Twit Text FOAVip T follicular helper and T follicular regulatory cells have different TCR specificity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28429709 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28429709 #FOAvip English Wikipedia <ref>{{Cite pmid|28429709}}</ref> T follicular helper and T follicular regulatory cells have different TCR specificity #MMPMID28429709 Maceiras AR; Almeida SCP; Mariotti-Ferrandiz E; Chaara W; Jebbawi F; Six A; Hori S; Klatzmann D; Faro J; Graca L Nat Commun 2017[]; 8 (ä): ä PMID28429709show ga Immunization leads to the formation of germinal centres (GCs) that contain both T follicular helper (Tfh) and T follicular regulatory (Tfr) cells. Whether T-cell receptor (TCR) specificity defines the differential functions of Tfh and Tfr cells is unclear. Here we show that antigen-specific T cells after immunization are preferentially recruited to the GC to become Tfh cells, but not Tfr cells. Tfh cells, but not Tfr cells, also proliferate efficiently on restimulation with the same immunizing antigen in vitro. Ex vivo TCR repertoire analysis shows that immunization induces oligoclonal expansion of Tfh cells. By contrast, the Tfr pool has a TCR repertoire that more closely resembles that of regulatory T (Treg) cells. Our data thus indicate that the GC Tfh and Tfr pools are generated from distinct TCR repertoires, with Tfh cells expressing antigen-responsive TCRs to promote antibody responses, and Tfr cells expressing potentially autoreactive TCRs to suppress autoimmunity. äT follicular helper and T follicular regulatory cells have different T(epmc).pdf DeepDyve Pubget Overpricing