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10.1098/rsob.160311 http://scihub22266oqcxt.onion/10.1098/rsob.160311 C5413903!5413903 !28446707     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28446707 &cmd=llinks): Failed to open stream: HTTP request failed! 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Deterministic versus stochastic model of reprogramming: new evidence from cellular barcoding technique |pdf=|usr=}}{{28446707 }} gab.com Text Deterministic versus stochastic model of reprogramming: new evidence from cellular barcoding technique JO: Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=28446707 #FOAvip Factor-mediated reprogramming of somatic cells towards pluripotency is a low-efficiency process during which only small subsets of cells are successfully reprogrammed. Previous analyses of the determinants of the reprogramming potential are based on average measurements across a large population of cells or on monitoring a relatively small number of single cells with live imaging. Here, we applied lentiviral genetic barcoding, a powerful tool enabling the identification of familiar relationships in thousands of cells. High-throughput sequencing of barcodes from successfully reprogrammed cells revealed a significant number of barcodes from related cells. We developed a computer model, according to which a probability of synchronous reprogramming of sister cells equals 10-30%. We conclude that the reprogramming success is pre-established in some particular cells and, being a heritable trait, can be maintained through cell division. Thus, reprogramming progresses in a deterministic manner, at least at the level of cell lineages. Twit Text FOAVip Deterministic versus stochastic model of reprogramming: new evidence from cellular barcoding technique ????Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=28446707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28446707 #FOAvip English Wikipedia <ref>{{Cite pmid|28446707 }}</ref> Deterministic versus stochastic model of reprogramming: new evidence from cellular barcoding technique #MMPMID28446707 Yunusova AM ; Fishman VS ; Vasiliev GV ; Battulin NR Open Biol 2017[Apr]; 7 (4 ): ä PMID28446707 show ga Factor-mediated reprogramming of somatic cells towards pluripotency is a low-efficiency process during which only small subsets of cells are successfully reprogrammed. Previous analyses of the determinants of the reprogramming potential are based on average measurements across a large population of cells or on monitoring a relatively small number of single cells with live imaging. Here, we applied lentiviral genetic barcoding, a powerful tool enabling the identification of familiar relationships in thousands of cells. High-throughput sequencing of barcodes from successfully reprogrammed cells revealed a significant number of barcodes from related cells. We developed a computer model, according to which a probability of synchronous reprogramming of sister cells equals 10-30%. We conclude that the reprogramming success is pre-established in some particular cells and, being a heritable trait, can be maintained through cell division. Thus, reprogramming progresses in a deterministic manner, at least at the level of cell lineages. |*Cellular Reprogramming [MESH] |*Models, Biological [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Doxycycline/pharmacology [MESH] |Embryo, Mammalian/cytology [MESH] |Fibroblasts/cytology/metabolism [MESH] |Genetic Vectors/genetics/metabolism [MESH] |Green Fluorescent Proteins/genetics/metabolism [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Induced Pluripotent Stem Cells/cytology/drug effects/*metabolism [MESH] |Lentivirus/genetics [MESH] |Mice [MESH] |Recombinant Fusion Proteins/biosynthesis/genetics [MESH] |Sequence Analysis, DNA [MESH] |Time-Lapse Imaging [MESH]Deterministic versus stochastic model of reprogramming: new evidence f(epmc).pdf DeepDyve Pubget Overpricing