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2015 ; 4
(2
): 126-130
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Successful treatment of severe crescentic lupus nephritis by multi-target therapy
using tacrolimus and mycophenolate mofetil
#MMPMID28509085
Mochizuki K
; Kayakabe K
; Hiromura K
; Ando M
; Sakurai N
; Ikeuchi H
; Sakairi T
; Kaneko Y
; Maeshima A
; Nojima Y
CEN Case Rep
2015[Nov]; 4
(2
): 126-130
PMID28509085
show ga
Treatment of severe lupus nephritis (LN) has been controversial, and according to
recent guidelines and recommendations, cyclophosphamide still remains a
first-line therapy. Herein, we present the case of a 37-year-old female patient
who developed rapidly progressive glomerulonephritis, which was histologically
diagnosed as class IV + V LN, with a large number of cellular to fibrocellular
crescents (62 % of glomeruli). Although the patient was considered to have the
most severe form of LN, complete remission was achieved within 6 months by
multi-target therapy using tacrolimus and mycophenolate mofetil combined with
methylprednisolone pulse therapy. Our experience suggests that multi-target
therapy could be a potential treatment option for patients with severe crescentic
LN.