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2013 ; 2
(1
): 123-127
Nephropedia Template TP
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A case of MPO- and PR3-ANCA-negative pauci-immune renal-limited small-vessel
vasculitis associated with endometrial neuroendocrine small cell carcinoma
#MMPMID28509232
Kaneko S
; Tsukamoto Y
; Abe K
; Yonamine M
; Hasegawa S
; Hikida H
CEN Case Rep
2013[May]; 2
(1
): 123-127
PMID28509232
show ga
A 69-year-old woman was admitted to our hospital for rapid increase in serum
creatinine level with microscopic hematuria and nephrotic-range proteinuria.
Three months prior to admission, she became aware of atypical genital bleeding,
leading her gynecologist to suspect endometrial cancer. Light microscopy
examination of renal biopsy revealed crescentic glomerulonephritis with
peritubular capillaritis. Immunofluorescence microscopic examination did not
detect any significant staining, and no electron-dense deposits were detected by
electron microscopy. No autoantibodies, including anti-myeloperoxidase- or
anti-proteinase3-anti-neutrophil cytoplasmic antibodies were detected. The
patient underwent total abdominal hysterectomy and bilateral
salpingo-oophorectomy and was found to have endometrial neuroendocrine small cell
carcinoma (NSCC), stage 1B. In her clinical course, her serum creatinine level
gradually improved without immunosuppression therapy. Endometrial NSCC is a rare
endometrial malignancy. This is the first case report of vasculitis associated
with NSCC originating from the uterus.