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Hepatitis C virus-related glomerulonephritis with acute kidney injury requiring
hemodialysis that improved with virus removal and eradication using
double-filtration plasmapheresis without interferon
#MMPMID28509265
Morisue A
; Fukuoka K
; Goto R
; Ota K
; Yamashita H
; Shinno Y
; Yamadori I
CEN Case Rep
2015[May]; 4
(1
): 38-42
PMID28509265
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A 66-year-old, hepatitis C virus (HCV)-positive woman was admitted to our
hospital with oliguria, systemic edema, and rapid deterioration of renal
function. Laboratory examination showed increased serum creatinine and decreased
serum albumin levels, complement activity, and cryoglobulin positivity. The HCV
RNA genotype was found to be 1b, and the viral load was high. Kidney biopsy
examination showed type I membranoproliferative glomerulonephritis with capillary
deposition of IgM and C3, indicating HCV-related glomerulonephritis. After
hospitalization, hemodialysis was immediately required because of uremia and
oliguria. Her renal function did not improve despite corticosteroid therapy. To
treat the increasing HCV load, virus removal and eradication by double-filtration
plasmapheresis therapy without interferon was performed, since the patient was
allergic to interferon therapy. This treatment improved renal function and
allowed the withdrawal from hemodialysis. This report presents a case of
successful VRAD without interferon therapy in a patient with HCV-related
glomerulonephritis and acute kidney injury that required hemodialysis.
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