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10.1007/s13730-013-0075-0

http://scihub22266oqcxt.onion/10.1007/s13730-013-0075-0
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C5413671!5413671!28509236
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suck abstract from ncbi


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pmid28509236      CEN+Case+Rep 2014 ; 3 (1): 10-3
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  • Renal cell neoplasm of oncocytosis: a type of unclassified renal cell carcinoma #MMPMID28509236
  • Shinohara M; Samma S; Matsumoto Y; Kagebayashi Y; Nakai Y; Torimoto K; Shimada K
  • CEN Case Rep 2014[May]; 3 (1): 10-3 PMID28509236show ga
  • A 69-year-old woman was referred to us because a cyst in the lower pole of the left kidney had been pointed out on screening ultrasound. Computed tomography (CT) demonstrated a mural nodule of the wall of the cyst with an enhancement effect, suggesting cystic renal cell carcinoma (cT1aN0M0). The patient underwent retroperitoneoscopic non-ischemic partial nephrectomy using a microwave tissue coagulator. A hematoxylin?eosin-stained specimen showed that the wall of the cystic tumor consisted of the proliferation of large cells with rich eosinophilic granules in the cytoplasm and round-shaped nuclei, which were the characteristics of oncocytoma. This was followed by immunohistochemical studies, because of findings of local cell invasion, mitosis, and necrosis, suggesting malignancy. The results were: CK7, strongly positive; PAX2, negative; colloidal iron stain, negative; c-kit, weakly positive; vimentin, positive; and RCC marker, negative. Thus, although the tumor showed characteristics of oncocytoma and/or chromophobe renal cell carcinoma (pT1a), it could not be classified according to the known categories: it should be designated as renal cell carcinoma (neoplasm) of oncocytosis, a novel category of unclassified renal cell carcinomas. The present case indicated the fact that renal cell carcinomas resembling oncocytoma certainly exist.
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