Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28509192
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 CEN+Case+Rep
2014 ; 3
(2
): 172-177
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Two cases of minor glomerular abnormalities with proteinuria disproportionate to
the degree of hypoproteinemia
#MMPMID28509192
Takashima T
; Onozawa K
; Rikitake S
; Kishi T
; Miyazono M
; Aoki S
; Sakemi T
; Ikeda Y
CEN Case Rep
2014[Nov]; 3
(2
): 172-177
PMID28509192
show ga
We experienced two female cases of minor glomerular abnormalities with
proteinuria disproportionate to the degree of hypoproteinemia. They did not have
adequately large amounts of urine protein so as to cause nephrotic syndrome;
however, we were unable to determine any cause of hypoproteinemia other than
proteinuria. The renal pathology revealed foot process effacement, and hyaline
droplet degeneration, suggesting urine protein hyper-reabsorption in the proximal
convoluted tubule. Therefore, we thought these cases involved pathophysiological
conditions, such as minimal change nephrotic syndrome. In both cases, the
hypoproteinemia improved following the administration of oral prednisolone. As in
past reports, it is thought that the principal causative factor of
hypoalbuminemia in patients with nephrotic syndrome is a catabolic reaction after
the serum albumin filtered at the glomerulus is reabsorbed in the proximal
tubule. In the present two cases, it is supposed that a large amount of urine
protein was filtered in the primitive urine; however, the amount of final urinary
protein did not reach the nephrotic range because most of it was reabsorbed in
the proximal tubule and reabsorbed in the blood after being disintegrated into
amino acids by a catabolic reaction. Or we might simply observe the process
before the case 1 got nephrotic syndrome and the healing process of nephrotic
syndrome in the case 2.