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2012 ; 1
(2
): 96-103
Nephropedia Template TP
gab.com Text
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English Wikipedia
The combined use of edaravone, diuretics, and nonsteroidal anti-inflammatory
drugs caused acute kidney injury in an elderly patient with chronic kidney
disease
#MMPMID28509068
Liu GJ
; Wang YF
; Zeng YJ
; Ding L
; Luo GJ
; Zhang LP
; Zhang J
CEN Case Rep
2012[Nov]; 1
(2
): 96-103
PMID28509068
show ga
The purpose of this study was to draw attention to the fact that the combined use
of edaravone, diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs) may
lead to acute kidney injury. This study was a case report of acute kidney injury
resulting from the combined use of the aforementioned types of drugs. A
77-year-old male patient with chronic kidney disease (third stage) who was
treated with a combination of edaravone, diuretics, and NSAIDs showed
significantly increased blood urea nitrogen and creatinine. Interestingly, the
blood urea nitrogen and creatinine levels returned to pretreatment levels after
the medications were stopped. The patient's score on the Naranjo Adverse Drug
Reaction Probability Scale was a nine, and the score on the Drug Interaction
Probability Scale was a five. For elderly patients with chronic kidney disease,
the combined use of edaravone, diuretics, and NSAIDs should be avoided.