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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Surg+Oncol
2017 ; 24
(6
): 1507-1515
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Fewer Reoperations After Lumpectomy for Breast Cancer with Neoadjuvant Rather
than Adjuvant Chemotherapy: A Report from the National Cancer Database
#MMPMID28062931
Landercasper J
; Bennie B
; Parsons BM
; Dietrich LL
; Greenberg CC
; Wilke LG
; Linebarger JH
Ann Surg Oncol
2017[Jun]; 24
(6
): 1507-1515
PMID28062931
show ga
BACKGROUND: Reoperations occur frequently after initial lumpectomy for breast
cancer. The authors hypothesized that the receipt of neoadjuvant chemotherapy
(NAC) is associated with fewer reoperations. METHODS: The association between
timing of chemotherapy and reoperation rates (ROR) after lumpectomy was
investigated for patients with stages 1-3 breast cancer in the National Cancer
Database (NCDB) from 2010 to 2013 by multivariable logistic regression modeling.
Then propensity score-matching was performed. RESULTS: The unadjusted ROR for
71,627 stages 1-3 patients was 11.4% for those who had NAC compared with 20.3%
for those who had postoperative chemotherapy (p < 0.001) (odds ratio [OR] 0.53;
95% confidence interval [CI] 0.49-0.57; p < 0.001). The ORs for the reoperations
performed for patients with stages 1, 2, and 3 cancers who received NAC were
respectively 0.65 (95% CI 0.56-0.75), 0.50 (95% CI 0.45-0.56), and 0.27 (95% CI
0.19-0.38) The p values for all were lower than 0.001. CONCLUSION: For a
population of patients receiving chemotherapy, the receipt of chemotherapy before
instead of after surgery was associated with fewer reoperations after initial
lumpectomy for breast cancer.