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10.1245/s10434-016-5760-8

http://scihub22266oqcxt.onion/10.1245/s10434-016-5760-8
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suck abstract from ncbi


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pmid28062931
      Ann+Surg+Oncol 2017 ; 24 (6 ): 1507-1515
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  • Fewer Reoperations After Lumpectomy for Breast Cancer with Neoadjuvant Rather than Adjuvant Chemotherapy: A Report from the National Cancer Database #MMPMID28062931
  • Landercasper J ; Bennie B ; Parsons BM ; Dietrich LL ; Greenberg CC ; Wilke LG ; Linebarger JH
  • Ann Surg Oncol 2017[Jun]; 24 (6 ): 1507-1515 PMID28062931 show ga
  • BACKGROUND: Reoperations occur frequently after initial lumpectomy for breast cancer. The authors hypothesized that the receipt of neoadjuvant chemotherapy (NAC) is associated with fewer reoperations. METHODS: The association between timing of chemotherapy and reoperation rates (ROR) after lumpectomy was investigated for patients with stages 1-3 breast cancer in the National Cancer Database (NCDB) from 2010 to 2013 by multivariable logistic regression modeling. Then propensity score-matching was performed. RESULTS: The unadjusted ROR for 71,627 stages 1-3 patients was 11.4% for those who had NAC compared with 20.3% for those who had postoperative chemotherapy (p < 0.001) (odds ratio [OR] 0.53; 95% confidence interval [CI] 0.49-0.57; p < 0.001). The ORs for the reoperations performed for patients with stages 1, 2, and 3 cancers who received NAC were respectively 0.65 (95% CI 0.56-0.75), 0.50 (95% CI 0.45-0.56), and 0.27 (95% CI 0.19-0.38) The p values for all were lower than 0.001. CONCLUSION: For a population of patients receiving chemotherapy, the receipt of chemotherapy before instead of after surgery was associated with fewer reoperations after initial lumpectomy for breast cancer.
  • |*Databases, Factual [MESH]
  • |*Mastectomy [MESH]
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Breast Neoplasms/drug therapy/pathology/*surgery [MESH]
  • |Chemotherapy, Adjuvant/*statistics & numerical data [MESH]
  • |Female [MESH]
  • |Follow-Up Studies [MESH]
  • |Humans [MESH]
  • |Middle Aged [MESH]
  • |Neoadjuvant Therapy/*statistics & numerical data [MESH]
  • |Prognosis [MESH]
  • |Reoperation/*statistics & numerical data [MESH]
  • |Second-Look Surgery/*statistics & numerical data [MESH]
  • |Survival Rate [MESH]


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