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10.1007/8904_2016_578

http://scihub22266oqcxt.onion/10.1007/8904_2016_578
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C5413455!5413455!27450368
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suck abstract from ncbi


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pmid27450368      JIMD+Rep 2017 ; 33 (ä): 33-9
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  • Management of Life-Threatening Tracheal Stenosis and Tracheomalacia in Patients with Mucopolysaccharidoses #MMPMID27450368
  • Kampmann C; Wiethoff CM; Huth RG; Staatz G; Mengel E; Beck M; Gehring S; Mewes T; Abu-Tair T; Baumgartner MR; Patterson M; Rahman S; Peters V; Morava E; Zschocke J
  • JIMD Rep 2017[]; 33 (ä): 33-9 PMID27450368show ga
  • Several different lysosomal storage diseases, mainly mucopolysaccharidosis (MPS) type I, II, and VI, are complicated by severe obstruction of the upper airways, tracheobronchial malacia, and/or stenosis of the lower airways. Although enzyme replacement therapies (ERTs) are available, the impact of these on tracheobronchial alterations has not been reported. By extending the life expectancy of MPS patients with ERTs, airway problems may become more prevalent at advanced ages. These airway abnormalities can result in severe, potentially fatal, difficulties during anesthetic procedures. Usually, upper airway obstruction is treated by tracheostomy. However, with lower airway malacia and/or stenosis, there are no procedures available to date to address these difficulties. We report the first cases using a new technique of tracheal stenting in patients with MPS type VI (Maroteaux?Lamy syndrome) and type II (Hunter syndrome) who had almost complete tracheal occlusion and total airway collapse. An updated literature review is also reported.
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