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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Transplant 2017 ; 31 (5): ä Nephropedia Template TP
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LONG TERM SURVIVAL FOLLOWING KIDNEY TRANSPLANTATION IN PREVIOUS LUNG TRANSPLANT RECIPIENTS - AN ANALYSIS OF THE UNOS REGISTRY #MMPMID28295652
Clin Transplant 2017[May]; 31 (5): ä PMID28295652show ga
BACKGROUND: Kidney transplantation has been advocated as a therapeutic option in lung recipients who develop end-stage renal disease. This analysis outlines patterns of allograft survival following kidney transplantation in previous lung recipients (KAL). METHODS: Data from the UNOS lung and kidney transplantation registries (1987?2013) were cross-linked to identify lung recipients who were subsequently listed for and/or underwent kidney transplantation. Time-dependent Cox models compared survival in KAL patients vs. those waitlisted for renal transplantation who never received kidneys. Survival analyses compared outcomes between KAL patients and risk-matched recipients of primary, kidney-only transplantation with no history of lung transplantation (KTx). RESULTS: 270 lung recipients subsequently underwent kidney transplantation (KAL). Regression models demonstrated a lower risk of post-listing mortality for KAL patients compared with 346 lung recipients on the kidney waitlist who never received kidneys (p<0.05). Comparisons between matched KAL and KTx patients demonstrated significantly increased risk of death and graft loss (p<0.05), but not death-censored graft loss, for KAL patients (p=0.86). CONCLUSIONS: KAL patients enjoy a significant survival benefit compared with waitlisted lung recipients who do not receive kidneys. However, KAL patients do poorly compared with KTx patients. Decisions about KAL transplantation must be made on a case-by-case basis considering patient and donor factors.