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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Exp+Med 2017 ; 214 (5): 1205-6 Nephropedia Template TP
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MINK1: The missing link between ROS and its inhibition of Th17 cells #MMPMID28420734
Martinez GJ
J Exp Med 2017[May]; 214 (5): 1205-6 PMID28420734show ga
In this issue of JEM, Fu et al. identified the kinase Mink1 as a novel negative regulator of Th17 cell generation. Mink1, activated by reactive oxygen species (ROS), prevents TGF-? activation of Smad2, therefore limiting Th17 cell differentiation.