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10.1084/jem.20161120

http://scihub22266oqcxt.onion/10.1084/jem.20161120
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C5413330!5413330!28400474
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suck abstract from ncbi


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pmid28400474      J+Exp+Med 2017 ; 214 (5): 1453-69
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  • Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1 #MMPMID28400474
  • Fu G; Xu Q; Qiu Y; Jin X; Xu T; Dong S; Wang J; Ke Y; Hu H; Cao X; Wang D; Cantor H; Gao X; Lu L
  • J Exp Med 2017[May]; 214 (5): 1453-69 PMID28400474show ga
  • Fu et al. demonstrate that reactive oxygen species (ROS)?sensing molecule misshapen/NIK-related kinase 1 (MINK1) can specifically suppress Th 17 cell differentiation through direct phosphorylation of SMAD2. This study provides the mechanism of how ROS limit inflammatory response and unveils the potential health risk of antioxidant supplementation.
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