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10.1038/s41551-016-0005 http://scihub22266oqcxt.onion/10.1038/s41551-016-0005 C5412959!5412959!28480128     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Biomed+Eng 2017 ; 1 (1): ä Nephropedia Template TP {{tp|p=28480128|t=2017. Self-adjusting synthetic gene circuit for correcting insulin resistance |pdf=|usr=}}{{28480128}} gab.com Text Self-adjusting synthetic gene circuit for correcting insulin resistance JO: Nat Biomed Eng http://www.kidney.de/pget.php?&tw=1&pmid=28480128 #FOAvip By using tools from synthetic biology, sophisticated genetic devices can be assembled to reprogram mammalian cell activities. Here, we demonstrate that a self-adjusting synthetic gene circuit can be designed to sense and reverse the insulin-resistance syndrome in different mouse models. By functionally rewiring the mitogen-activated protein kinase (MAPK) signalling pathway to produce MAPK-mediated activation of the hybrid transcription factor TetR-ELK1, we assembled a synthetic insulin-sensitive transcription-control device that self-sufficiently distinguished between physiological and increased blood insulin levels and correspondingly fine-tuned the reversible expression of therapeutic transgenes from synthetic TetR-ELK1-specific promoters. In acute experimental hyperinsulinemia, the synthetic insulin-sensing designer circuit reversed the insulin-resistance syndrome by coordinating expression of the insulin-sensitizing compound adiponectin. Engineering synthetic gene circuits to sense pathologic markers and coordinate the expression of therapeutic transgenes may provide opportunities for future gene- and cell-based treatments of multifactorial metabolic disorders. Twit Text FOAVip Self-adjusting synthetic gene circuit for correcting insulin resistance ????Nat Biomed Eng http://www.kidney.de/pget.php?&tw=1&pmid=28480128 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28480128 #FOAvip English Wikipedia <ref>{{Cite pmid|28480128}}</ref> Self-adjusting synthetic gene circuit for correcting insulin resistance #MMPMID28480128 Ye H; Xie M; Xue S; Charpin-El Hamri G; Yin J; Zulewski H; Fussenegger M Nat Biomed Eng 2017[Jan]; 1 (1): ä PMID28480128show ga By using tools from synthetic biology, sophisticated genetic devices can be assembled to reprogram mammalian cell activities. Here, we demonstrate that a self-adjusting synthetic gene circuit can be designed to sense and reverse the insulin-resistance syndrome in different mouse models. By functionally rewiring the mitogen-activated protein kinase (MAPK) signalling pathway to produce MAPK-mediated activation of the hybrid transcription factor TetR-ELK1, we assembled a synthetic insulin-sensitive transcription-control device that self-sufficiently distinguished between physiological and increased blood insulin levels and correspondingly fine-tuned the reversible expression of therapeutic transgenes from synthetic TetR-ELK1-specific promoters. In acute experimental hyperinsulinemia, the synthetic insulin-sensing designer circuit reversed the insulin-resistance syndrome by coordinating expression of the insulin-sensitizing compound adiponectin. Engineering synthetic gene circuits to sense pathologic markers and coordinate the expression of therapeutic transgenes may provide opportunities for future gene- and cell-based treatments of multifactorial metabolic disorders. äSelf-adjusting synthetic gene circuit for correcting insulin resistanc(epmc).pdf DeepDyve Pubget Overpricing