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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Cardiol
2017 ; 40
(4
): 243-254
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gab.com Text
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English Wikipedia
PCSK9 inhibitor access barriers-issues and recommendations: Improving the access
process for patients, clinicians and payers
#MMPMID28328015
Baum SJ
; Toth PP
; Underberg JA
; Jellinger P
; Ross J
; Wilemon K
Clin Cardiol
2017[Apr]; 40
(4
): 243-254
PMID28328015
show ga
The proprotein convertase subtilisin/kexin type 9 inhibitors or monoclonal
antibodies likely represent the greatest advance in lipid management in 30 years.
In 2015 the US Food and Drug Administration approved both alirocumab and
evolocumab for high-risk patients with familial hypercholesterolemia (FH) and
clinical atherosclerotic cardiovascular disease requiring additional lowering of
low-density lipoprotein cholesterol. Though many lipid specialists,
cardiovascular disease prevention experts, endocrinologists, and others
prescribed the drugs on label, they found their directives denied 80% to 90% of
the time. The high frequency of denials prompted the American Society for
Preventive Cardiology (ASPC), to gather multiple stakeholder organizations
including the American College of Cardiology, National Lipid Association,
American Association of Clinical Endocrinologists (AACE), and FH Foundation for 2
town hall meetings to identify access issues and implement viable solutions. This
article reviews findings recognized and solutions suggested by experts during
these discussions. The article is a product of the ASPC, along with each author
writing as an individual and endorsed by the AACE.