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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Cell+Biol 2017 ; 216 (5): 1357-69 Nephropedia Template TP
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Preprotein mature domains contain translocase targeting signals that are essential for secretion #MMPMID28404644
Chatzi KE; Sardis MF; Tsirigotaki A; Koukaki M; ?o?tari? N; Konijnenberg A; Sobott F; Kalodimos CG; Karamanou S; Economou A
J Cell Biol 2017[May]; 216 (5): 1357-69 PMID28404644show ga
Secretory preproteins contain a mature domain fused to a signal peptide that targets the protein to the translocase, which mediates secretion. In this study, the authors show that the mature domains bear independent targeting signals (MTS) that consist of multiple, degenerate, interchangeable, linear or 3D hydrophobic stretches that are essential for proper secretion.