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10.1083/jcb.201608039

http://scihub22266oqcxt.onion/10.1083/jcb.201608039
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C5412561!5412561!28404643
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suck abstract from ncbi


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pmid28404643      J+Cell+Biol 2017 ; 216 (5): 1301-20
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  • The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy #MMPMID28404643
  • Liu X; Li Y; Wang X; Xing R; Liu K; Gan Q; Tang C; Gao Z; Jian Y; Luo S; Guo W; Yang C
  • J Cell Biol 2017[May]; 216 (5): 1301-20 PMID28404643show ga
  • Mutations in WDR81, a regulator of the endosomal?lysosomal pathway, are implicated in CAMRQ2 syndrome, which manifests as cerebellar ataxia, mental retardation, and quadrupedal locomotion in patients. In this study, Liu et al. uncover a distinct function of WDR81 in the clearance of ubiquitinated and aggregated proteins by autophagy.
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