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10.1186/s12915-017-0375-5 http://scihub22266oqcxt.onion/10.1186/s12915-017-0375-5 C5412054!5412054!28464931     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Biol 2017 ; 15 (ä): ä Nephropedia Template TP {{tp|p=28464931|t=2017. The biological function of the cellular prion protein: an update |pdf=|usr=}}{{28464931}} gab.com Text The biological function of the cellular prion protein: an update JO: BMC Biol http://www.kidney.de/pget.php?&tw=1&pmid=28464931 #FOAvip The misfolding of the cellular prion protein (PrPC) causes fatal neurodegenerative diseases. Yet PrPC is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary elimination. Ablation of PrPC in mice results in well-defined structural and functional alterations in the peripheral nervous system. Many additional phenotypes were ascribed to the lack of PrPC, but some of these were found to arise from genetic artifacts of the underlying mouse models. Here, we revisit the proposed physiological roles of PrPC in the central and peripheral nervous systems and highlight the need for their critical reassessment using new, rigorously controlled animal models. Twit Text FOAVip The biological function of the cellular prion protein: an update ????BMC Biol http://www.kidney.de/pget.php?&tw=1&pmid=28464931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28464931 #FOAvip English Wikipedia <ref>{{Cite pmid|28464931}}</ref> The biological function of the cellular prion protein: an update #MMPMID28464931 Wulf MA; Senatore A; Aguzzi A BMC Biol 2017[]; 15 (ä): ä PMID28464931show ga The misfolding of the cellular prion protein (PrPC) causes fatal neurodegenerative diseases. Yet PrPC is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary elimination. Ablation of PrPC in mice results in well-defined structural and functional alterations in the peripheral nervous system. Many additional phenotypes were ascribed to the lack of PrPC, but some of these were found to arise from genetic artifacts of the underlying mouse models. Here, we revisit the proposed physiological roles of PrPC in the central and peripheral nervous systems and highlight the need for their critical reassessment using new, rigorously controlled animal models. äThe biological function of the cellular prion protein: an update (epmc).pdf DeepDyve Pubget Overpricing