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10.1038/ncomms11607 http://scihub22266oqcxt.onion/10.1038/ncomms11607 C5411730!5411730!27197754     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27197754|t=2016. Adaptive evolution of complex innovations through stepwise metabolic niche expansion |pdf=|usr=}}{{27197754}} gab.com Text Adaptive evolution of complex innovations through stepwise metabolic niche expansion JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27197754 #FOAvip A central challenge in evolutionary biology concerns the mechanisms by which complex metabolic innovations requiring multiple mutations arise. Here, we propose that metabolic innovations accessible through the addition of a single reaction serve as stepping stones towards the later establishment of complex metabolic features in another environment. We demonstrate the feasibility of this hypothesis through three complementary analyses. First, using genome-scale metabolic modelling, we show that complex metabolic innovations in Escherichia coli can arise via changing nutrient conditions. Second, using phylogenetic approaches, we demonstrate that the acquisition patterns of complex metabolic pathways during the evolutionary history of bacterial genomes support the hypothesis. Third, we show how adaptation of laboratory populations of E. coli to one carbon source facilitates the later adaptation to another carbon source. Our work demonstrates how complex innovations can evolve through series of adaptive steps without the need to invoke non-adaptive processes. Twit Text FOAVip Adaptive evolution of complex innovations through stepwise metabolic niche expansion ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27197754 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27197754 #FOAvip English Wikipedia <ref>{{Cite pmid|27197754}}</ref> Adaptive evolution of complex innovations through stepwise metabolic niche expansion #MMPMID27197754 Szappanos B; Fritzemeier J; Csörg? B; Lázár V; Lu X; Fekete G; Bálint B; Herczeg R; Nagy I; Notebaart RA; Lercher MJ; Pál C; Papp B Nat Commun 2016[]; 7 (ä): ä PMID27197754show ga A central challenge in evolutionary biology concerns the mechanisms by which complex metabolic innovations requiring multiple mutations arise. Here, we propose that metabolic innovations accessible through the addition of a single reaction serve as stepping stones towards the later establishment of complex metabolic features in another environment. We demonstrate the feasibility of this hypothesis through three complementary analyses. First, using genome-scale metabolic modelling, we show that complex metabolic innovations in Escherichia coli can arise via changing nutrient conditions. Second, using phylogenetic approaches, we demonstrate that the acquisition patterns of complex metabolic pathways during the evolutionary history of bacterial genomes support the hypothesis. Third, we show how adaptation of laboratory populations of E. coli to one carbon source facilitates the later adaptation to another carbon source. Our work demonstrates how complex innovations can evolve through series of adaptive steps without the need to invoke non-adaptive processes. äAdaptive evolution of complex innovations through stepwise metabolic n(epmc).pdf DeepDyve Pubget Overpricing