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2016 ; 5
(2
): 163-167
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Glomerulopathy with distinctive fibrillar deposits but lacking glomerular
deposition of type III collagen
#MMPMID28508970
Yamamoto T
; Togawa A
; Eguchi M
; Ohashi N
; Yasuda H
; Harita Y
; Hattori M
; Yamaguchi Y
; Ohyama K
CEN Case Rep
2016[Nov]; 5
(2
): 163-167
PMID28508970
show ga
A 62-year-old woman with nephrotic syndrome underwent a renal biopsy. Under light
microscopy, the biopsy findings included lobulation and enlargement of glomeruli,
occasional thickening of glomerular capillary walls, and narrowing of the
capillary lumen by swollen endothelial cells. Congo red staining was negative for
amyloid. No significant intraglomerular fibrin deposition was found by
phosphotungstic acid hematoxylin staining. Immunofluorescence microscopy showed
no deposition of immunoglobulin G, A, or M; no ? or ? light chains; and no C3 or
C1q. Electron microscopy revealed distinctive subendothelial and mesangial
fibrillar deposits, mesangial cell interposition, and swelling and vacuolization
of endothelial cells resulting in capillary lumen narrowing. Although some
curvilinear fibrillar deposits mimicked the bundles of type III collagen fibers
seen in collagenofibrotic glomerulopathy, neither glomerular deposition of type
III collagen nor elevation of serum procollagen III peptide was noted. This
glomerulopathy does not fulfill any known disease entities with non-amyloid
non-immunoglobulin-derived organized glomerular deposits.