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2013 ; 2
(2
): 248-251
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Development of minimal-change glomerular disease and Hashimoto s thyroiditis
during the treatment of sarcoidosis
#MMPMID28509299
Ando F
; Okado T
; Sohara E
; Rai T
; Uchida S
; Sasaki S
CEN Case Rep
2013[Nov]; 2
(2
): 248-251
PMID28509299
show ga
Minimal-change glomerular disease, sarcoidosis and autoimmune thyroid disease
rarely occur in the same patient. We herein report a patient in which
minimal-change glomerular disease and Hashimoto's thyroiditis developed during
the treatment of sarcoidosis with steroids. A 66-year-old female was admitted to
our hospital with symptoms of nephrotic syndrome. Nine months before admission,
she was diagnosed as having ocular and pulmonary sarcoidosis, for which
prednisolone at an initial dose of 40 mg/day was started. When the dose of
prednisolone was tapered to 20 mg/day, she noticed swelling of the lower
extremities. Examination confirmed the simultaneous occurrence of minimal-change
glomerular disease and Hashimoto's thyroiditis, which were diagnosed based on
kidney histology, ultrasonography of the thyroid gland and positive
antithyroglobulin antibodies. We used intravenous methylprednisolone pulse
therapy followed by 40 mg/day oral prednisolone. The patient achieved complete
remission of nephrotic syndrome and steroids were tapered without relapse.