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Long-term prognosis of 4 children with steroid-sensitive nephrotic syndrome and
relapse after 30 years of age
#MMPMID28509256
Motoyama O
; Sakai K
; Iitaka K
CEN Case Rep
2014[May]; 3
(1
): 106-109
PMID28509256
show ga
Some children with steroid-sensitive nephrotic syndrome (SSNS) have been reported
to suffer relapses in adulthood, but the clinical course of such adults is
unclear. Four children with SSNS suffered relapses after 30 years of age. Those 4
patients developed frequently relapsing nephrotic syndrome (NS) between 2 and
10 years of age. They were treated with prednisolone (PSL) combined with
cyclophosphamide in 3 patients, mizoribine in 2, and cyclosporine in 1 during
childhood, and with cyclosporine in 2 during adulthood. After 20 years of age,
the frequency of relapses gradually decreased. The last relapse occurred between
33 and 39 years of age, and proteinuria disappeared within 1 month after the
start of treatment with PSL. At the last follow-up, all 4 patients continued to
receive PSL, had normal renal function, and were in complete remission of NS when
they were between 33 and 41 years of age. Although the long-term outcome of SSNS
is usually considered to be favorable, pediatricians should be aware that some
children with SSNS may require long-term treatment during adulthood.
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