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10.1371/journal.pcbi.1005486 http://scihub22266oqcxt.onion/10.1371/journal.pcbi.1005486 C5411097!5411097!28414716     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Comput+Biol 2017 ; 13 (4): ä Nephropedia Template TP {{tp|p=28414716|t=2017. Dynamics of adaptive immunity against phage in bacterial populations |pdf=|usr=}}{{28414716}} gab.com Text Dynamics of adaptive immunity against phage in bacterial populations JO: PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=28414716 #FOAvip The CRISPR (clustered regularly interspaced short palindromic repeats) mechanism allows bacteria to adaptively defend against phages by acquiring short genomic sequences (spacers) that target specific sequences in the viral genome. We propose a population dynamical model where immunity can be both acquired and lost. The model predicts regimes where bacterial and phage populations can co-exist, others where the populations exhibit damped oscillations, and still others where one population is driven to extinction. Our model considers two key parameters: (1) ease of acquisition and (2) spacer effectiveness in conferring immunity. Analytical calculations and numerical simulations show that if spacers differ mainly in ease of acquisition, or if the probability of acquiring them is sufficiently high, bacteria develop a diverse population of spacers. On the other hand, if spacers differ mainly in their effectiveness, their final distribution will be highly peaked, akin to a ?winner-take-all? scenario, leading to a specialized spacer distribution. Bacteria can interpolate between these limiting behaviors by actively tuning their overall acquisition probability. Twit Text FOAVip Dynamics of adaptive immunity against phage in bacterial populations ????PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=28414716 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28414716 #FOAvip English Wikipedia <ref>{{Cite pmid|28414716}}</ref> Dynamics of adaptive immunity against phage in bacterial populations #MMPMID28414716 Bradde S; Vucelja M; Te?ileanu T; Balasubramanian V PLoS Comput Biol 2017[Apr]; 13 (4): ä PMID28414716show ga The CRISPR (clustered regularly interspaced short palindromic repeats) mechanism allows bacteria to adaptively defend against phages by acquiring short genomic sequences (spacers) that target specific sequences in the viral genome. We propose a population dynamical model where immunity can be both acquired and lost. The model predicts regimes where bacterial and phage populations can co-exist, others where the populations exhibit damped oscillations, and still others where one population is driven to extinction. Our model considers two key parameters: (1) ease of acquisition and (2) spacer effectiveness in conferring immunity. Analytical calculations and numerical simulations show that if spacers differ mainly in ease of acquisition, or if the probability of acquiring them is sufficiently high, bacteria develop a diverse population of spacers. On the other hand, if spacers differ mainly in their effectiveness, their final distribution will be highly peaked, akin to a ?winner-take-all? scenario, leading to a specialized spacer distribution. Bacteria can interpolate between these limiting behaviors by actively tuning their overall acquisition probability. äDynamics of adaptive immunity against phage in bacterial populations (epmc).pdf DeepDyve Pubget Overpricing