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10.3389/fendo.2017.00078 http://scihub22266oqcxt.onion/10.3389/fendo.2017.00078 C5410625!5410625!28507533     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Endocrinol+(Lausanne) 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28507533|t=2017. Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K |pdf=|usr=}}{{28507533}} gab.com Text Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K JO: Front Endocrinol (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=28507533 #FOAvip Type I and II cytokine receptors are cell surface sensors that bind cytokines in the extracellular environment and initiate intracellular signaling to control processes such as hematopoiesis, immune function, and cellular growth and development. One key mechanism that regulates signaling from cytokine receptors is through receptor endocytosis. In this mini-review, we describe recent advances in endocytic regulations of cytokine receptors, focusing on new paradigms by which PI3K controls receptor endocytosis through both kinase activity-dependent and -independent mechanisms. These advances underscore the notion that the p85 regulatory subunit of PI3K has functions beyond regulating PI3K kinase activity, and that PI3K plays both positive and negative roles in receptor signaling. On the one hand, the PI3K/Akt pathway controls various aspects downstream of cytokine receptors. On the other hand, it stimulates receptor endocytosis and downregulation, thus contributing to signaling attenuation. Twit Text FOAVip Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K ????Front Endocrinol (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=28507533 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28507533 #FOAvip English Wikipedia <ref>{{Cite pmid|28507533}}</ref> Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K #MMPMID28507533 Chen Ph; Yao H; Huang LJs Front Endocrinol (Lausanne) 2017[]; 8 (ä): ä PMID28507533show ga Type I and II cytokine receptors are cell surface sensors that bind cytokines in the extracellular environment and initiate intracellular signaling to control processes such as hematopoiesis, immune function, and cellular growth and development. One key mechanism that regulates signaling from cytokine receptors is through receptor endocytosis. In this mini-review, we describe recent advances in endocytic regulations of cytokine receptors, focusing on new paradigms by which PI3K controls receptor endocytosis through both kinase activity-dependent and -independent mechanisms. These advances underscore the notion that the p85 regulatory subunit of PI3K has functions beyond regulating PI3K kinase activity, and that PI3K plays both positive and negative roles in receptor signaling. On the one hand, the PI3K/Akt pathway controls various aspects downstream of cytokine receptors. On the other hand, it stimulates receptor endocytosis and downregulation, thus contributing to signaling attenuation. äCytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Inde(epmc).pdf DeepDyve Pubget Overpricing