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10.1016/S2215-0366(17)30015-9 http://scihub22266oqcxt.onion/10.1016/S2215-0366(17)30015-9 C5410405!5410405!28153641     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lancet+Psychiatry 2017 ; 4 (5): 409-18 Nephropedia Template TP {{tp|p=28153641|t=2017. How do antidepressants work? New perspectives for refining future treatment approaches |pdf=|usr=}}{{28153641}} gab.com Text How do antidepressants work New perspectives for refining future treatment approaches JO: Lancet Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=28153641 #FOAvip Most currently available antidepressants target monoamine neurotransmitter function. However, a purely neurotransmitter-based explanation for antidepressant drug action is challenged by the delayed clinical onset of most agents and the need to explain how neurochemical changes reverse the many different symptoms of depression. Novel approaches to understanding of antidepressant drug action include a focus on early changes in emotional and social processing and the role of neural plasticity. In this Review, we discuss the ways in which these two different theories reflect different or complementary approaches, and how they might be integrated to offer novel solutions for people with depression. We consider the predictions made by these mechanistic approaches for the stratification and development of new therapeutics for depression, and the next steps that need to be made to facilitate this translation of science to the clinic. Twit Text FOAVip How do antidepressants work New perspectives for refining future treatment approaches ????Lancet Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=28153641 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28153641 #FOAvip English Wikipedia <ref>{{Cite pmid|28153641}}</ref> How do antidepressants work? New perspectives for refining future treatment approaches #MMPMID28153641 Harmer CJ; Duman RS; Cowen PJ Lancet Psychiatry 2017[May]; 4 (5): 409-18 PMID28153641show ga Most currently available antidepressants target monoamine neurotransmitter function. However, a purely neurotransmitter-based explanation for antidepressant drug action is challenged by the delayed clinical onset of most agents and the need to explain how neurochemical changes reverse the many different symptoms of depression. Novel approaches to understanding of antidepressant drug action include a focus on early changes in emotional and social processing and the role of neural plasticity. In this Review, we discuss the ways in which these two different theories reflect different or complementary approaches, and how they might be integrated to offer novel solutions for people with depression. We consider the predictions made by these mechanistic approaches for the stratification and development of new therapeutics for depression, and the next steps that need to be made to facilitate this translation of science to the clinic. äHow do antidepressants work? New perspectives for refining future trea(epmc).pdf DeepDyve Pubget Overpricing