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10.18632/oncotarget.15485 http://scihub22266oqcxt.onion/10.18632/oncotarget.15485 C5410288!5410288!28416743     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (14): 23099-109 Nephropedia Template TP {{tp|p=28416743|t=2017. The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis |pdf=|usr=}}{{28416743}} gab.com Text The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28416743 #FOAvip Background: The urokinase plasminogen activation (uPA) system is a crucial pathway for tumour invasion and establishment of metastasis. Although there is good evidence that uPA system expression is a clinically relevant biomarker in some solid tumours, its role in gastroesophageal cancer is uncertain. Results: We identified 22 studies encompassing 1966 patients which fulfilled the inclusion criteria. uPA, uPAR, or PAI-1 expression is significantly associated with high risk clinicopathological features. High uPA expression is associated with a shorter RFS (HR 1.90 95% 1.16?3.11, p = 0.01) and OS (HR 2.21 95% CI 1.74?2.80, p < 0.0001). High uPAR expression is associated with poorer OS (HR 2.21 95%CI 1.82?2.69, p < 0.0001). High PAI-1 expression is associated with shorter RFS (HR 1.96 96% CI 1.07?3.58, p = 0.03) and OS (HR 1.84 95%CI 1.28?2.64, p < 0.0001). There was no significant association between PAI-2 expression and OS (HR 0.97 95%CI 0.48?1.94, p < 0.92) although data was limited. Materials and Methods: We undertook a systematic review evaluating expression of uPA, urokinase plasminogen activator receptor (uPAR), plasminogen activator inhibitor-1 (PAI-1/SerpinE1) and plasminogen activator inhibitor-2 (PAI-2/SerpinB2) on primary oesophageal, gastro-oesophageal junction, and gastric adenocarcinomas. We performed a meta-analysis of clinicopathological associations, overall survival (OS) and recurrence free survival (RFS). Conclusions: We conclude that the uPA system is a clinically relevant biomarker in primary gastroesophageal cancer, with higher expression of uPA, uPAR and PAI-1 associated with higher risk disease and poorer prognosis. This also highlights the potential utility of the uPA system as a therapeutic target for improved treatment strategies. Twit Text FOAVip The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28416743 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28416743 #FOAvip English Wikipedia <ref>{{Cite pmid|28416743}}</ref> The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis #MMPMID28416743 Brungs D; Chen J; Aghmesheh M; Vine KL; Becker TM; Carolan MG; Ranson M Oncotarget 2017[Apr]; 8 (14): 23099-109 PMID28416743show ga Background: The urokinase plasminogen activation (uPA) system is a crucial pathway for tumour invasion and establishment of metastasis. Although there is good evidence that uPA system expression is a clinically relevant biomarker in some solid tumours, its role in gastroesophageal cancer is uncertain. Results: We identified 22 studies encompassing 1966 patients which fulfilled the inclusion criteria. uPA, uPAR, or PAI-1 expression is significantly associated with high risk clinicopathological features. High uPA expression is associated with a shorter RFS (HR 1.90 95% 1.16?3.11, p = 0.01) and OS (HR 2.21 95% CI 1.74?2.80, p < 0.0001). High uPAR expression is associated with poorer OS (HR 2.21 95%CI 1.82?2.69, p < 0.0001). High PAI-1 expression is associated with shorter RFS (HR 1.96 96% CI 1.07?3.58, p = 0.03) and OS (HR 1.84 95%CI 1.28?2.64, p < 0.0001). There was no significant association between PAI-2 expression and OS (HR 0.97 95%CI 0.48?1.94, p < 0.92) although data was limited. Materials and Methods: We undertook a systematic review evaluating expression of uPA, urokinase plasminogen activator receptor (uPAR), plasminogen activator inhibitor-1 (PAI-1/SerpinE1) and plasminogen activator inhibitor-2 (PAI-2/SerpinB2) on primary oesophageal, gastro-oesophageal junction, and gastric adenocarcinomas. We performed a meta-analysis of clinicopathological associations, overall survival (OS) and recurrence free survival (RFS). Conclusions: We conclude that the uPA system is a clinically relevant biomarker in primary gastroesophageal cancer, with higher expression of uPA, uPAR and PAI-1 associated with higher risk disease and poorer prognosis. This also highlights the potential utility of the uPA system as a therapeutic target for improved treatment strategies. äThe urokinase plasminogen activation system in gastroesophageal cancer(epmc).pdf DeepDyve Pubget Overpricing