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10.18632/oncotarget.15152 http://scihub22266oqcxt.onion/10.18632/oncotarget.15152 C5410252!5410252!28186988     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (14): 22649-61 Nephropedia Template TP {{tp|p=28186988|t=2017. HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma |pdf=|usr=}}{{28186988}} gab.com Text HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28186988 #FOAvip Human malignant mesothelioma (MM) is an aggressive cancer linked to asbestos and erionite exposure. We previously reported that High-Mobility Group Box-1 protein (HMGB1), a prototypic damage-associated molecular pattern, drives MM development and sustains MM progression. Moreover, we demonstrated that targeting HMGB1 inhibited MM cell growth and motility in vitro, reduced tumor growth in vivo, and prolonged survival of MM-bearing mice. Ethyl pyruvate (EP), the ethyl ester of pyruvic acid, has been shown to be an effective HMGB1 inhibitor in inflammation-related diseases and several cancers. Here, we studied the effect of EP on the malignant phenotype of MM cells in tissue culture and on tumor growth in vivo using an orthotopic MM xenograft model. We found that EP impairs HMGB1 secretion by MM cells leading to reduced RAGE expression and NF-?B activation. As a consequence, EP impaired cell motility, cell proliferation, and anchorage-independent growth of MM cells. Moreover, EP reduced HMGB1 serum levels in mice and inhibited the growth of MM xenografts.Our results indicate that EP effectively hampers the malignant phenotype of MM, offering a novel potential therapeutic approach to patients afflicted with this dismal disease. Twit Text FOAVip HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28186988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28186988 #FOAvip English Wikipedia <ref>{{Cite pmid|28186988}}</ref> HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma #MMPMID28186988 Pellegrini L; Xue J; Larson D; Pastorino S; Jube S; Forest KH; Saad-Jube ZS; Napolitano A; Pagano I; Negi VS; Bianchi ME; Morris P; Pass HI; Gaudino G; Carbone M; Yang H Oncotarget 2017[Apr]; 8 (14): 22649-61 PMID28186988show ga Human malignant mesothelioma (MM) is an aggressive cancer linked to asbestos and erionite exposure. We previously reported that High-Mobility Group Box-1 protein (HMGB1), a prototypic damage-associated molecular pattern, drives MM development and sustains MM progression. Moreover, we demonstrated that targeting HMGB1 inhibited MM cell growth and motility in vitro, reduced tumor growth in vivo, and prolonged survival of MM-bearing mice. Ethyl pyruvate (EP), the ethyl ester of pyruvic acid, has been shown to be an effective HMGB1 inhibitor in inflammation-related diseases and several cancers. Here, we studied the effect of EP on the malignant phenotype of MM cells in tissue culture and on tumor growth in vivo using an orthotopic MM xenograft model. We found that EP impairs HMGB1 secretion by MM cells leading to reduced RAGE expression and NF-?B activation. As a consequence, EP impaired cell motility, cell proliferation, and anchorage-independent growth of MM cells. Moreover, EP reduced HMGB1 serum levels in mice and inhibited the growth of MM xenografts.Our results indicate that EP effectively hampers the malignant phenotype of MM, offering a novel potential therapeutic approach to patients afflicted with this dismal disease. äHMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of hu(epmc).pdf DeepDyve Pubget Overpricing