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Mesenchymal Stem Cells for the Delivery of Oncolytic Viruses in Gliomas #MMPMID28233640
Parker Kerrigan BC; Shimizu Y; Andreeff M; Lang FF
Cytotherapy 2017[Apr]; 19 (4): 445-57 PMID28233640show ga
Mesenchymal stem cells (MSCs) are a type of adult stem cell that have been exploited for the treatment of a variety of diseases, including cancer. In particular, MSCs have been studied extensively for their ability to treat glioblastoma (GBM), the most common and deadly form of brain cancer in adults. MSCs are attractive therapeutics because they can be obtained relatively easily from patients, are capable of being expanded in vitro, can be easily engineered, and because they inherently are capable of homing to tumors, making them ideal vehicles for delivering biological anti-tumoral agents. Oncolytic viruses are promising biological therapeutic agents that have been employed in the treatment of GBMs, and MSCs are currently being explored as means of delivering these viruses. Here we review the role of MSCs in the treatment of GBMs, focusing on the intersection of MSCs and oncolytic viruses.