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2017 ; 18
(1
): 224
Nephropedia Template TP
gab.com Text
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English Wikipedia
MYCbase: a database of functional sites and biochemical properties of Myc in both
normal and cancer cells
#MMPMID28454513
Chakravorty D
; Jana T
; Das Mandal S
; Seth A
; Bhattacharya A
; Saha S
BMC Bioinformatics
2017[Apr]; 18
(1
): 224
PMID28454513
show ga
BACKGROUND: Myc is an essential gene having multiple functions such as in cell
growth, differentiation, apoptosis, genomic stability, angiogenesis, and disease
biology. A large number of researchers dedicated to Myc biology are generating a
substantial amount of data in normal and cancer cells/tissues including Burkitt's
lymphoma and ovarian cancer. RESULTS: MYCbase (
http://bicresources.jcbose.ac.in/ssaha4/mycbase ) is a collection of
experimentally supported functional sites in Myc that can influence the
biological cellular processes. The functional sites were compiled according to
their role which includes mutation, methylation pattern, post-translational
modifications, protein-protein interactions (PPIs), and DNA interactions. In
addition, biochemical properties of Myc are also compiled, which includes
metabolism/pathway, protein abundance, and modulators of protein-protein
interactions. The OMICS data related to Myc- like gene expression, proteomics
expression using mass-spectrometry and miRNAs targeting Myc were also compiled in
MYCbase. The mutation and pathway data from the MYCbase were analyzed to look at
the patterns and distributions across different diseases. There were few
proteins/genes found common in Myc-protein interactions and Myc-DNA binding, and
these can play a significant role in transcriptional feedback loops. CONCLUSION:
In this report, we present a comprehensive integration of relevant information
regarding Myc in the form of MYCbase. The data compiled in MYCbase provides a
reliable data resource for functional sites at the residue level and biochemical
properties of Myc in various cancers.
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