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10.1016/j.tibs.2017.02.006

http://scihub22266oqcxt.onion/10.1016/j.tibs.2017.02.006
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C5409865!5409865!28284537
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suck abstract from ncbi

pmid28284537      Trends+Biochem+Sci 2017 ; 42 (5): 342-54
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  • Proteome-scale human interactomics #MMPMID28284537
  • Luck K; Sheynkman GM; Zhang I; Vidal M
  • Trends Biochem Sci 2017[May]; 42 (5): 342-54 PMID28284537show ga
  • Cellular functions are mediated by complex interactome networks of physical, biochemical, and functional interactions between DNA sequences, RNA molecules, proteins, lipids, and small metabolites. A thorough understanding of cellular organization requires accurate and relatively complete models of interactome networks at proteome-scale. The recent publication of four human protein-protein interaction (PPI) maps represents a technological breakthrough and an unprecedented resource for the scientific community, heralding a new era of proteome-scale human interactomics. Our knowledge gained from these and complementary studies provides fresh insights into the opportunities and challenges when analyzing systematically generated interactome data, defines a clear roadmap towards the generation of a first reference interactome, and reveals new perspectives on the organization of cellular life.
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