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10.1016/j.cels.2017.02.013 http://scihub22266oqcxt.onion/10.1016/j.cels.2017.02.013 C5409831!5409831 !28342717     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28342717 &cmd=llinks): Failed to open stream: HTTP request failed! 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Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity |pdf=|usr=}}{{28342717 }} gab.com Text Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity JO: Cell Syst http://www.kidney.de/pget.php?&tw=1&pmid=28342717 #FOAvip Genes targeted by Polycomb repressive complex 2 (PRC2) are regulated in cis by chromatin modifications and also in trans by diffusible regulators such as transcription factors. Here, we introduce a mathematical model in which transcription directly antagonizes Polycomb silencing, thereby linking these cis- and trans-regulatory inputs to gene expression. The model is parameterized by recent experimental data showing that PRC2-mediated repressive chromatin modifications accumulate extremely slowly. The model generates self-perpetuating, bistable active and repressed chromatin states that persist through DNA replication, thereby ensuring high-fidelity transmission of the current chromatin state. However, sufficiently strong, persistent activation or repression of transcription promotes switching between active and repressed chromatin states. We observe that when chromatin modification dynamics are slow, transient pulses of transcriptional activation or repression are effectively filtered, such that epigenetic memory is retained. Noise filtering thus depends on slow chromatin dynamics and may represent an important function of PRC2-based regulation. Twit Text FOAVip Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity ????Cell Syst http://www.kidney.de/pget.php?&tw=1&pmid=28342717 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28342717 #FOAvip English Wikipedia <ref>{{Cite pmid|28342717 }}</ref> Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity #MMPMID28342717 Berry S ; Dean C ; Howard M Cell Syst 2017[Apr]; 4 (4 ): 445-457.e8 PMID28342717 show ga Genes targeted by Polycomb repressive complex 2 (PRC2) are regulated in cis by chromatin modifications and also in trans by diffusible regulators such as transcription factors. Here, we introduce a mathematical model in which transcription directly antagonizes Polycomb silencing, thereby linking these cis- and trans-regulatory inputs to gene expression. The model is parameterized by recent experimental data showing that PRC2-mediated repressive chromatin modifications accumulate extremely slowly. The model generates self-perpetuating, bistable active and repressed chromatin states that persist through DNA replication, thereby ensuring high-fidelity transmission of the current chromatin state. However, sufficiently strong, persistent activation or repression of transcription promotes switching between active and repressed chromatin states. We observe that when chromatin modification dynamics are slow, transient pulses of transcriptional activation or repression are effectively filtered, such that epigenetic memory is retained. Noise filtering thus depends on slow chromatin dynamics and may represent an important function of PRC2-based regulation. |*Models, Genetic [MESH] |Chromatin Assembly and Disassembly [MESH] |Chromatin/metabolism/*physiology [MESH] |Epigenesis, Genetic [MESH] |Gene Expression Regulation/physiology [MESH] |Histones/metabolism/physiology [MESH] |Methylation [MESH]Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuat(epmc).pdf DeepDyve Pubget Overpricing