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Plantago asiatica L Ameliorates Puromycin Aminonucleoside-Induced Nephrotic
Syndrome by Suppressing Inflammation and Apoptosis
#MMPMID28420111
Kho MC
; Park JH
; Han BH
; Tan R
; Yoon JJ
; Kim HY
; Ahn YM
; Lee YJ
; Kang DG
; Lee HS
Nutrients
2017[Apr]; 9
(4
): ? PMID28420111
show ga
OBJECTIVE: Nephrotic syndrome, a kidney disease with a variety of causes, is
mainly characterized by heavy proteinuria, hypoproteinemia, and ascites. This
study was designed to evaluate the underlying mechanism of action of Plantago
asiatica L. (PAL) in treating nephrotic syndrome induced by puromycin
aminonucleoside. METHODS: PAL has been used in Asia as a traditional medicine and
dietary health supplement. Sprague-Dawley (SD) rats were intravenously injected
with puromycin aminonucleoside (75 mg/kg/day), then treated with either Losartan
(30 mg/kg/day) or PAL (200 mg/kg/day) by oral gavage for seven days. RESULTS: PAL
significantly decreased ascites, proteinuria level, and plasma lipid parameters.
In addition, treatment with PAL attenuated histological damage and
hypoalbuminemia. Treatment with PAL also restored podocin expression and reduced
inflammation markers such as intracellular adhesion molecules (ICAM-1), monocyte
chemotactic protein-1 (MCP-1), tumor necrosis factor alpha (TNF-?) and
high-mobility group box-1 (HMGB1). Lower expression levels of the apoptosis
markers Bax, caspase-3 and capase-9 were documented in SD rats receiving PAL. PAL
also significantly decreased the phosphorylation levels of MAPKs such as ERK, JNK
and p38. CONCLUSION: As a multifunctional agent, PAL has a renoprotective effect
in nephrotic syndrome rat models. The anti-inflammatory and anti-apoptotic
properties, along with reductions in hyperlipidemia and ascites, represent
important therapeutic effects. These results indicate that Plantago asiatica is
likely to be a promising agent in the treatment of nephrotic syndrome.
|*Plantago
[MESH]
|Animals
[MESH]
|Apoptosis/*drug effects
[MESH]
|Ascites
[MESH]
|Biomarkers/blood
[MESH]
|Caspase 3/blood
[MESH]
|Caspase 9/blood
[MESH]
|Hypoalbuminemia/prevention & control
[MESH]
|Inflammation/blood/*prevention & control
[MESH]
|Intracellular Signaling Peptides and Proteins/blood
[MESH]
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