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10.3390/nu9040345

http://scihub22266oqcxt.onion/10.3390/nu9040345
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suck abstract from ncbi


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pmid28362355
      Nutrients 2017 ; 9 (4 ): ä
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  • Daily Intake of Grape Powder Prevents the Progression of Kidney Disease in Obese Type 2 Diabetic ZSF1 Rats #MMPMID28362355
  • Almomen SM ; Guan Q ; Liang P ; Yang K ; Sidiqi AM ; Levin A ; Du C
  • Nutrients 2017[Mar]; 9 (4 ): ä PMID28362355 show ga
  • Individuals living with metabolic syndrome (MetS) such as diabetes and obesity are at high risk for developing chronic kidney disease (CKD). This study investigated the beneficial effect of whole grape powder (WGP) diet on MetS-associated CKD. Obese diabetic ZSF1 rats, a kidney disease model with MetS, were fed WGP (5%, w/w) diet for six months. Kidney disease was determined using blood and urine chemical analyses, and histology. When compared to Vehicle controls, WGP intake did not change the rat bodyweight, but lowered their kidney, liver and spleen weight, which were in parallel with the lower serum glucose and the higher albumin or albumin/globin ratio. More importantly, WGP intake improved the renal function as urination and proteinuria decreased, or it prevented kidney tissue damage in these diabetic rats. The renal protection of WGP diet was associated with up-regulation of antioxidants (Dhcr24, Gstk1, Prdx2, Sod2, Gpx1 and Gpx4) and downregulation of Txnip (for ROS production) in the kidneys. Furthermore, addition of grape extract reduced H?O?-induced cell death of cultured podocytes. In conclusion, daily intake of WGP reduces the progression of kidney disease in obese diabetic rats, suggesting a protective function of antioxidant-rich grape diet against CKD in the setting of MetS.
  • |*Dietary Supplements [MESH]
  • |Animals [MESH]
  • |Antioxidants/isolation & purification/metabolism/*therapeutic use [MESH]
  • |Biomarkers/blood/urine [MESH]
  • |Cell Line [MESH]
  • |Crosses, Genetic [MESH]
  • |Diabetes Mellitus, Type 2/*complications [MESH]
  • |Diabetic Nephropathies/complications/*diet therapy/metabolism/physiopathology [MESH]
  • |Disease Progression [MESH]
  • |Fruit/chemistry [MESH]
  • |Gene Expression Regulation [MESH]
  • |Kidney/metabolism/pathology/physiopathology [MESH]
  • |Male [MESH]
  • |Metabolic Syndrome/complications [MESH]
  • |Mice [MESH]
  • |Organ Size [MESH]
  • |Oxidative Stress [MESH]
  • |Plant Preparations/isolation & purification/metabolism/*therapeutic use [MESH]
  • |Podocytes/metabolism/pathology [MESH]
  • |Random Allocation [MESH]
  • |Rats, Inbred SHR [MESH]
  • |Rats, Zucker [MESH]
  • |Renal Insufficiency, Chronic/complications/*diet therapy/metabolism/physiopathology [MESH]


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