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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nutrients
2017 ; 9
(4
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Daily Intake of Grape Powder Prevents the Progression of Kidney Disease in Obese
Type 2 Diabetic ZSF1 Rats
#MMPMID28362355
Almomen SM
; Guan Q
; Liang P
; Yang K
; Sidiqi AM
; Levin A
; Du C
Nutrients
2017[Mar]; 9
(4
): ä PMID28362355
show ga
Individuals living with metabolic syndrome (MetS) such as diabetes and obesity
are at high risk for developing chronic kidney disease (CKD). This study
investigated the beneficial effect of whole grape powder (WGP) diet on
MetS-associated CKD. Obese diabetic ZSF1 rats, a kidney disease model with MetS,
were fed WGP (5%, w/w) diet for six months. Kidney disease was determined using
blood and urine chemical analyses, and histology. When compared to Vehicle
controls, WGP intake did not change the rat bodyweight, but lowered their kidney,
liver and spleen weight, which were in parallel with the lower serum glucose and
the higher albumin or albumin/globin ratio. More importantly, WGP intake improved
the renal function as urination and proteinuria decreased, or it prevented kidney
tissue damage in these diabetic rats. The renal protection of WGP diet was
associated with up-regulation of antioxidants (Dhcr24, Gstk1, Prdx2, Sod2, Gpx1
and Gpx4) and downregulation of Txnip (for ROS production) in the kidneys.
Furthermore, addition of grape extract reduced H?O?-induced cell death of
cultured podocytes. In conclusion, daily intake of WGP reduces the progression of
kidney disease in obese diabetic rats, suggesting a protective function of
antioxidant-rich grape diet against CKD in the setting of MetS.
|*Dietary Supplements
[MESH]
|Animals
[MESH]
|Antioxidants/isolation & purification/metabolism/*therapeutic use
[MESH]