Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Stem+Cell 2016 ; 18 (1): 39-52 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Material Cues as Potent Regulators of Epigenetics and Stem Cell Function #MMPMID26748755
Crowder SW; Leonardo V; Whittaker T; Papathanasiou P; Stevens MM
Cell Stem Cell 2016[Jan]; 18 (1): 39-52 PMID26748755show ga
Biophysical signals act as potent regulators of stem cell function, lineage commitment, and epigenetic status. In recent years, synthetic biomaterials have been used to study a wide range of outside-in signaling events, and it is now well appreciated that material cues modulate the epigenetic status of cells. Here, we review the role of extracellular signals in guiding stem cell behavior via epigenetic regulation, and stress the role of physicochemical material properties as an often-overlooked modulator of intracellular signaling. We also highlight promising new research tools for ongoing interrogation of the stem cell-material interface.