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10.1038/nn.4528 http://scihub22266oqcxt.onion/10.1038/nn.4528 C5409501!5409501!28288125     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Neurosci 2017 ; 20 (5): 674-80 Nephropedia Template TP {{tp|p=28288125|t=2017. Regulatory T cells promote myelin regeneration in the Central Nervous System |pdf=|usr=}}{{28288125}} gab.com Text Regulatory T cells promote myelin regeneration in the Central Nervous System JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28288125 #FOAvip Regeneration of central nervous system (CNS) myelin involves differentiation of oligodendrocytes from oligodendrocyte progenitor cells (OPC). In multiple sclerosis (MS), remyelination can fail despite abundant OPC, suggesting impairment of oligodendrocyte differentiation. T cells infiltrate the CNS during MS, yet little is known about T cell functions in remyelination. Here, we report that regulatory T cells (Treg) promote oligodendrocyte differentiation and (re)myelination. Treg-deficient mice exhibited significantly impaired remyelination and oligodendrocyte differentiation that was rescued by adoptive transfer of Treg. In brain slice cultures, Treg accelerated developmental myelination and remyelination, even in the absence of overt inflammation. Treg directly promoted OPC differentiation and myelination in vitro. We identified CCN3 as a novel Treg-derived mediator of oligodendrocyte differentiation and myelination in vitro. These findings reveal a new regenerative function of Treg in the CNS, distinct from immunomodulation. Although originally named ?Treg? to reflect immunoregulatory roles, this also captures emerging, regenerative Treg functions aptly. Twit Text FOAVip Regulatory T cells promote myelin regeneration in the Central Nervous System ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28288125 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28288125 #FOAvip English Wikipedia <ref>{{Cite pmid|28288125}}</ref> Regulatory T cells promote myelin regeneration in the Central Nervous System #MMPMID28288125 Dombrowski Y; O?Hagan T; Dittmer M; Penalva R; Mayoral SR; Bankhead P; Fleville S; Eleftheriadis G; Zhao C; Naughton M; Hassan R; Moffat J; Falconer J; Boyd A; Hamilton P; Allen IV; Kissenpfennig A; Moynagh PN; Evergren E; Perbal B; Williams AC; Ingram RJ; Chan JR; Franklin RJ; Fitzgerald DC Nat Neurosci 2017[May]; 20 (5): 674-80 PMID28288125show ga Regeneration of central nervous system (CNS) myelin involves differentiation of oligodendrocytes from oligodendrocyte progenitor cells (OPC). In multiple sclerosis (MS), remyelination can fail despite abundant OPC, suggesting impairment of oligodendrocyte differentiation. T cells infiltrate the CNS during MS, yet little is known about T cell functions in remyelination. Here, we report that regulatory T cells (Treg) promote oligodendrocyte differentiation and (re)myelination. Treg-deficient mice exhibited significantly impaired remyelination and oligodendrocyte differentiation that was rescued by adoptive transfer of Treg. In brain slice cultures, Treg accelerated developmental myelination and remyelination, even in the absence of overt inflammation. Treg directly promoted OPC differentiation and myelination in vitro. We identified CCN3 as a novel Treg-derived mediator of oligodendrocyte differentiation and myelination in vitro. These findings reveal a new regenerative function of Treg in the CNS, distinct from immunomodulation. Although originally named ?Treg? to reflect immunoregulatory roles, this also captures emerging, regenerative Treg functions aptly. äRegulatory T cells promote myelin regeneration in the Central Nervous (epmc).pdf DeepDyve Pubget Overpricing