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2017 ; 12
(4
): e0176014
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Potential biological pathways linking Type-D personality and poor health: A
cross-sectional investigation
#MMPMID28453522
PLoS One
2017[]; 12
(4
): e0176014
PMID28453522
show ga
BACKGROUND: Type-D personality, defined as a combination of high negative affect
and high social isolation, has been associated with poor health outcomes.
However, pathways underlying this association are largely unknown. We
investigated the relationship between Type-D personality and several biological
and behavioral pathways including the autonomic nervous system, the immune
system, glucose regulation and sleep in a large, apparently healthy sample.
METHODS: Data from a total of 646 respondents (age 41.6±11.5, 12,2% women) were
available for analysis. Persons with Type-D (negative affect and social isolation
score ?10) were contrasted with those without Type-D. Measures of plasma
fibrinogen levels, white blood cell count, high sensitivity C-reactive protein,
fasting plasma glucose (FPG), cholesterol, high-density and low-density
lipoprotein, glycated hemoglobin (HbA1c), creatinine, triglycerides, and albumin
were derived from fasting blood samples. Urine norepinephrine and free cortisol
were determined by high-performance liquid chromatography. Time-domain heart rate
variability (HRV) measures were calculated for the 24hr recording period and for
nighttime separately. RESULTS: Persons with Type-D had higher HbA1c, FPG, and
fibrinogen, and lower nighttime HRV than those without Type-D, suggesting worse
glycemic control, systemic inflammation and poorer autonomic nervous system
modulation in Type-D persons. In addition, those with Type-D reported less social
support and greater sleep difficulties while no group differences were observed
for alcohol and cigarette consumption, physical activity and body mass index.
CONCLUSIONS: Findings provide some of the first evidence for multiple possible
biological and behavioral pathways between Type-D personality and increased
morbidity and mortality.