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10.15252/msb.20167347 http://scihub22266oqcxt.onion/10.15252/msb.20167347 C5408781!5408781!28455348     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Syst+Biol 2017 ; 13 (4): ä Nephropedia Template TP {{tp|p=28455348|t=2017. A spectrum of modularity in multi?functional gene circuits |pdf=|usr=}}{{28455348}} gab.com Text A spectrum of modularity in multi functional gene circuits JO: Mol Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=28455348 #FOAvip A major challenge in systems biology is to understand the relationship between a circuit's structure and its function, but how is this relationship affected if the circuit must perform multiple distinct functions within the same organism? In particular, to what extent do multi?functional circuits contain modules which reflect the different functions? Here, we computationally survey a range of bi?functional circuits which show no simple structural modularity: They can switch between two qualitatively distinct functions, while both functions depend on all genes of the circuit. Our analysis reveals two distinct classes: hybrid circuits which overlay two simpler mono?functional sub?circuits within their circuitry, and emergent circuits, which do not. In this second class, the bi?functionality emerges from more complex designs which are not fully decomposable into distinct modules and are consequently less intuitive to predict or understand. These non?intuitive emergent circuits are just as robust as their hybrid counterparts, and we therefore suggest that the common bias toward studying modular systems may hinder our understanding of real biological circuits. Twit Text FOAVip A spectrum of modularity in multi functional gene circuits ????Mol Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=28455348 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28455348 #FOAvip English Wikipedia <ref>{{Cite pmid|28455348}}</ref> A spectrum of modularity in multi?functional gene circuits #MMPMID28455348 Jiménez A; Cotterell J; Munteanu A; Sharpe J Mol Syst Biol 2017[Apr]; 13 (4): ä PMID28455348show ga A major challenge in systems biology is to understand the relationship between a circuit's structure and its function, but how is this relationship affected if the circuit must perform multiple distinct functions within the same organism? In particular, to what extent do multi?functional circuits contain modules which reflect the different functions? Here, we computationally survey a range of bi?functional circuits which show no simple structural modularity: They can switch between two qualitatively distinct functions, while both functions depend on all genes of the circuit. Our analysis reveals two distinct classes: hybrid circuits which overlay two simpler mono?functional sub?circuits within their circuitry, and emergent circuits, which do not. In this second class, the bi?functionality emerges from more complex designs which are not fully decomposable into distinct modules and are consequently less intuitive to predict or understand. These non?intuitive emergent circuits are just as robust as their hybrid counterparts, and we therefore suggest that the common bias toward studying modular systems may hinder our understanding of real biological circuits. äA spectrum of modularity in multi?functional gene circuits (epmc).pdf DeepDyve Pubget Overpricing