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10.1016/j.celrep.2017.03.035 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.03.035 C5408750!5408750!28402853     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 19 (2): 295-306 Nephropedia Template TP {{tp|p=28402853|t=2017. Structure of nascent chromatin is essential for hematopoietic lineage specification |pdf=|usr=}}{{28402853}} gab.com Text Structure of nascent chromatin is essential for hematopoietic lineage specification JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28402853 #FOAvip The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34+ HPCs possess a post-replicative chromatin globally devoid of the repressive histone mark H3K27me3. This H3K27-unmodified chromatin is required for recruitment of lineage-determining transcription factors (TFs) C/EBP?, PU.1 and GATA-1 to DNA just after DNA replication upon cytokine-induced myeloid or erythroid commitment. Blocking DNA replication or increasing H3K27me3 levels prevents recruitment of these TFs to DNA and suppresses cytokine-induced erythroid or myeloid differentiation. However, H3K27me3 is rapidly associated with nascent DNA in more primitive human and murine HPCs. Treatment of these cells with instructive cytokines leads to a significant delay in accumulation of H3K27me3 in nascent chromatin due to activity of the H3K27me3 demethylase UTX. Thus, HPCs utilize special mechanisms of chromatin modification for recruitment of specific TFs to DNA during early stages of lineage specification. Twit Text FOAVip Structure of nascent chromatin is essential for hematopoietic lineage specification ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28402853 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28402853 #FOAvip English Wikipedia <ref>{{Cite pmid|28402853}}</ref> Structure of nascent chromatin is essential for hematopoietic lineage specification #MMPMID28402853 Petruk S; Mariani SA; De Dominici M; Porazzi P; Minieri V; Cai J; Iacovitti L; Flomenberg N; Calabretta B; Mazo A Cell Rep 2017[Apr]; 19 (2): 295-306 PMID28402853show ga The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34+ HPCs possess a post-replicative chromatin globally devoid of the repressive histone mark H3K27me3. This H3K27-unmodified chromatin is required for recruitment of lineage-determining transcription factors (TFs) C/EBP?, PU.1 and GATA-1 to DNA just after DNA replication upon cytokine-induced myeloid or erythroid commitment. Blocking DNA replication or increasing H3K27me3 levels prevents recruitment of these TFs to DNA and suppresses cytokine-induced erythroid or myeloid differentiation. However, H3K27me3 is rapidly associated with nascent DNA in more primitive human and murine HPCs. Treatment of these cells with instructive cytokines leads to a significant delay in accumulation of H3K27me3 in nascent chromatin due to activity of the H3K27me3 demethylase UTX. Thus, HPCs utilize special mechanisms of chromatin modification for recruitment of specific TFs to DNA during early stages of lineage specification. äStructure of nascent chromatin is essential for hematopoietic lineage (epmc).pdf DeepDyve Pubget Overpricing