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10.1186/s12866-017-1012-8 http://scihub22266oqcxt.onion/10.1186/s12866-017-1012-8 C5408368!5408368!28449650     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Microbiol 2017 ; 17 (ä): ä Nephropedia Template TP {{tp|p=28449650|t=2017. Structure, Genetics and Worldwide Spread of New Delhi Metallo-?-lactamase (NDM): a threat to public health |pdf=|usr=}}{{28449650}} gab.com Text Structure, Genetics and Worldwide Spread of New Delhi Metallo- -lactamase (NDM): a threat to public health JO: BMC Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28449650 #FOAvip Background: The emergence of carbapenemase producing bacteria, especially New Delhi metallo-?-lactamase (NDM-1) and its variants, worldwide, has raised amajor public health concern. NDM-1 hydrolyzes a wide range of ?-lactam antibiotics, including carbapenems, which are the last resort of antibiotics for the treatment of infections caused by resistant strain of bacteria. Main body: In this review, we have discussed blaNDM-1variants, its genetic analysis including type of specific mutation, origin of country and spread among several type of bacterial species. Wide members of enterobacteriaceae, most commonly Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and gram-negative non-fermenters Pseudomonas spp. and Acinetobacter baumannii were found to carry these markers. Moreover, at least seventeen variants of blaNDM-type gene differing into one or two residues of amino acids at distinct positions have been reported so far among different species of bacteria from different countries. The genetic and structural studies of these variants are important to understand the mechanism of antibiotic hydrolysis as well as to design new molecules with inhibitory activity against antibiotics. Conclusion: This review provides a comprehensive view of structural differences among NDM-1 variants, which are a driving force behind their spread across the globe. Electronic supplementary material: The online version of this article (doi:10.1186/s12866-017-1012-8) contains supplementary material, which is available to authorized users. Twit Text FOAVip Structure, Genetics and Worldwide Spread of New Delhi Metallo- -lactamase (NDM): a threat to public health ????BMC Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=28449650 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28449650 #FOAvip English Wikipedia <ref>{{Cite pmid|28449650}}</ref> Structure, Genetics and Worldwide Spread of New Delhi Metallo-?-lactamase (NDM): a threat to public health #MMPMID28449650 Khan AU; Maryam L; Zarrilli R BMC Microbiol 2017[]; 17 (ä): ä PMID28449650show ga Background: The emergence of carbapenemase producing bacteria, especially New Delhi metallo-?-lactamase (NDM-1) and its variants, worldwide, has raised amajor public health concern. NDM-1 hydrolyzes a wide range of ?-lactam antibiotics, including carbapenems, which are the last resort of antibiotics for the treatment of infections caused by resistant strain of bacteria. Main body: In this review, we have discussed blaNDM-1variants, its genetic analysis including type of specific mutation, origin of country and spread among several type of bacterial species. Wide members of enterobacteriaceae, most commonly Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and gram-negative non-fermenters Pseudomonas spp. and Acinetobacter baumannii were found to carry these markers. Moreover, at least seventeen variants of blaNDM-type gene differing into one or two residues of amino acids at distinct positions have been reported so far among different species of bacteria from different countries. The genetic and structural studies of these variants are important to understand the mechanism of antibiotic hydrolysis as well as to design new molecules with inhibitory activity against antibiotics. Conclusion: This review provides a comprehensive view of structural differences among NDM-1 variants, which are a driving force behind their spread across the globe. Electronic supplementary material: The online version of this article (doi:10.1186/s12866-017-1012-8) contains supplementary material, which is available to authorized users. äStructure, Genetics and Worldwide Spread of New Delhi Metallo-?-lactam(epmc).pdf DeepDyve Pubget Overpricing