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10.3390/toxins9040138 http://scihub22266oqcxt.onion/10.3390/toxins9040138 C5408212!5408212 !28406452     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28406452 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Toxins+(Basel) 2017 ; 9 (4 ): ä Nephropedia Template TP {{tp|p=28406452 |t=2017. Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGF?/Smad and MAPK-JNK Signaling Pathways |pdf=|usr=}}{{28406452 }} gab.com Text Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGF /Smad and MAPK-JNK Signaling Pathways JO: Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28406452 #FOAvip Transforming growth factor (TGF)-?1 plays a crucial role in the epithelial-to-mesenchymal transition (EMT) in hepatocytes and hepatic stellate cells (HSC), which contributes to the pathogenesis of liver fibrosis. Melittin (MEL) is a major component of bee venom and is effective in rheumatoid arthritis, pain relief, cancer cell proliferation, fibrosis and immune modulating activity. In this study, we found that MEL inhibits hepatic EMT in vitro and in vivo, regulating the TGF?/Smad and TGF?/nonSmad signaling pathways. MEL significantly inhibited TGF-?1-induced expression of EMT markers (E-cadherin reduction and vimentin induction) in vitro. These results were confirmed in CCl?-induced liver in vivo. Treatment with MEL almost completely blocked the phosphorylation of Smad2/3, translocation of Smad4 and phosphorylation of JNK in vitro and in vivo. Taken together, these results suggest that MEL suppresses EMT by inhibiting the TGF?/Smad and TGF?/nonSmad-c-Jun N-terminal kinase (JNK)/Mitogen-activated protein kinase (MAPK) signaling pathways. These results indicated that MEL possesses potent anti-fibrotic and anti-EMT properties, which may be responsible for its effects on liver diseases. Twit Text FOAVip Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGF /Smad and MAPK-JNK Signaling Pathways ????Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28406452 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28406452 #FOAvip English Wikipedia <ref>{{Cite pmid|28406452 }}</ref> Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGF?/Smad and MAPK-JNK Signaling Pathways #MMPMID28406452 Park JH ; Park B ; Park KK Toxins (Basel) 2017[Apr]; 9 (4 ): ä PMID28406452 show ga Transforming growth factor (TGF)-?1 plays a crucial role in the epithelial-to-mesenchymal transition (EMT) in hepatocytes and hepatic stellate cells (HSC), which contributes to the pathogenesis of liver fibrosis. Melittin (MEL) is a major component of bee venom and is effective in rheumatoid arthritis, pain relief, cancer cell proliferation, fibrosis and immune modulating activity. In this study, we found that MEL inhibits hepatic EMT in vitro and in vivo, regulating the TGF?/Smad and TGF?/nonSmad signaling pathways. MEL significantly inhibited TGF-?1-induced expression of EMT markers (E-cadherin reduction and vimentin induction) in vitro. These results were confirmed in CCl?-induced liver in vivo. Treatment with MEL almost completely blocked the phosphorylation of Smad2/3, translocation of Smad4 and phosphorylation of JNK in vitro and in vivo. Taken together, these results suggest that MEL suppresses EMT by inhibiting the TGF?/Smad and TGF?/nonSmad-c-Jun N-terminal kinase (JNK)/Mitogen-activated protein kinase (MAPK) signaling pathways. These results indicated that MEL possesses potent anti-fibrotic and anti-EMT properties, which may be responsible for its effects on liver diseases. |Animals [MESH] |Carbon Tetrachloride [MESH] |Cell Line [MESH] |Chemical and Drug Induced Liver Injury/drug therapy/metabolism [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Hepatic Stellate Cells/*drug effects/metabolism [MESH] |Hepatocytes/*drug effects/metabolism [MESH] |JNK Mitogen-Activated Protein Kinases/genetics/metabolism [MESH] |Liver Cirrhosis/drug therapy/metabolism [MESH] |Male [MESH] |Melitten/*pharmacology [MESH] |Mice, Inbred C57BL [MESH] |Rats [MESH] |Smad Proteins/genetics/metabolism [MESH]Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melitti(epmc).pdf DeepDyve Pubget Overpricing