Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.pharmthera.2017.02.012 http://scihub22266oqcxt.onion/10.1016/j.pharmthera.2017.02.012 C5407910!5407910!28174093     free     free     free       Pharmacol+Ther 2017 ; 173 (ä): 135-45 Nephropedia Template TP {{tp|p=28174093|t=2017. New Insights into Thyroid Hormone Action |pdf=|usr=}}{{28174093}} gab.com Text New Insights into Thyroid Hormone Action JO: Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=28174093 #FOAvip Thyroid hormones (TH) are endocrine messengers essential for normal development and function of virtually every vertebrate. The hypothalamic-pituitary-thyroid axis is exquisitely modulated to maintain nearly constant TH (T4 and T3) concentrations in circulation. However peripheral tissues and the CNS control the intracellular availability of TH, suggesting that circulating concentrations of TH are not fully representative of what each cell type sees. Indeed, recent work in the field has identified that TH transporters, deiodinases and thyroid hormone receptor coregulators can strongly control tissue-specific sensitivity to a set amount of TH. Furthermore, the mechanism by which the thyroid hormone receptors regulate target gene expression can vary by gene, tissue and cellular context. This review will highlight novel insights into the machinery that controls the cellular response to TH, which include unique signaling cascades. These findings shed new light into the pathophysiology of human diseases caused by abnormal TH signaling. Twit Text FOAVip New Insights into Thyroid Hormone Action ????Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=28174093 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28174093 #FOAvip English Wikipedia <ref>{{Cite pmid|28174093}}</ref> New Insights into Thyroid Hormone Action #MMPMID28174093 Mendoza A; Hollenberg AN Pharmacol Ther 2017[May]; 173 (ä): 135-45 PMID28174093show ga Thyroid hormones (TH) are endocrine messengers essential for normal development and function of virtually every vertebrate. The hypothalamic-pituitary-thyroid axis is exquisitely modulated to maintain nearly constant TH (T4 and T3) concentrations in circulation. However peripheral tissues and the CNS control the intracellular availability of TH, suggesting that circulating concentrations of TH are not fully representative of what each cell type sees. Indeed, recent work in the field has identified that TH transporters, deiodinases and thyroid hormone receptor coregulators can strongly control tissue-specific sensitivity to a set amount of TH. Furthermore, the mechanism by which the thyroid hormone receptors regulate target gene expression can vary by gene, tissue and cellular context. This review will highlight novel insights into the machinery that controls the cellular response to TH, which include unique signaling cascades. These findings shed new light into the pathophysiology of human diseases caused by abnormal TH signaling. äNew Insights into Thyroid Hormone Action (epmc).pdf DeepDyve Pubget Overpricing