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Human ductal plate and its derivatives express antigens of cholangiocellular,
hepatocellular, hepatic stellate/progenitor cell, stem cell, and neuroendocrine
lineages, and proliferative antigens
#MMPMID27075931
Terada T
Exp Biol Med (Maywood)
2017[May]; 242
(9
): 907-917
PMID27075931
show ga
Molecular mechanisms of human ductal plate (DP) development and differentiation
(DD) are unclear. The author immunohistochemically investigated expressions of
cholangiocellular antigens (CEA, CA19-9, EMA, MUC1, MUC2, MUC5AC, MUC6, mucins,
CK7, and CK19), hepatocellular antigens (HepPar1, AFP, CK8, and CK18), hepatic
stellate/progenitor cell (HSC) antigens or stem cell (SC) antigens (C-erbB2,
CD56, chromogranin, synaptophysin, bcl2, NSE, NCAM, KIT, and PDGFRA), and
proliferating antigen (Ki67) in 32 human fetal livers (HFL). The DD of human
intrahepatic bile duct (IBD) could be categorized into four stages: DP,
remodeling DP, remodeled DP, and immature IBD. All the molecules examined were
expressed in the DP and DP derivatives. These results suggest that human DP or DP
derivatives have capacities to differentiate into cholangiocellular,
hepatocellular, HSC, SC, and neuroendocrine lineages. The data also suggest that
NCAM, KIT/SC factor-signaling, NSE, HGF/MET signaling, PDGFa/PDGFRA signaling,
chromogranin, synaptophysin, and CD56 play important roles in DD of DP and
biliary cells of HFL. DP, DP derivatives, and IBD in HFL have proliferative
capacity.