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10.1152/ajpheart.00724.2016

http://scihub22266oqcxt.onion/10.1152/ajpheart.00724.2016
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C5407166!5407166!28188215
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suck abstract from ncbi


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pmid28188215      Am+J+Physiol+Heart+Circ+Physiol 2017 ; 312 (4): H711-20
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  • Cystathionine ?-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6 #MMPMID28188215
  • Leucker TM; Nomura Y; Kim JH; Bhatta A; Wang V; Wecker A; Jandu S; Santhanam L; Berkowitz D; Romer L; Pandey D
  • Am J Physiol Heart Circ Physiol 2017[Apr]; 312 (4): H711-20 PMID28188215show ga
  • Oxidative injury to endothelial cells by oxidized LDL reduced cystathionine ?-lyase (CSE?) expression and H2S production, leading to endothelial dysfunction, which was prevented by histone deacetylase 6 (HDAC6) inhibition. Our data suggest HDAC6 as a novel therapeutic target to prevent the development of atherosclerosis.
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